摘要
急性胰腺炎(AP)是一种严重的炎症性疾病,其特征是胰腺组织的自身消化和炎症反应。近年来的研究揭示了肠道菌群与AP之间的密切联系。肠道微生物群落是由数以万亿计微生物组成的复杂生态系统,与宿主的多种生理活动密切相关,包括代谢过程、免疫系统调节及肠道结构维持。然而,肠道菌群的失衡被认为在AP的发生发展中扮演了关键角色,这种失衡不仅影响肠道屏障的完整性,还可能通过多种机制加剧炎症反应,从而影响疾病的严重程度和患者的临床预后。本文综述了肠道菌群在AP中的作用机制,探讨了肠道菌群失衡如何影响疾病的进程,并评估了当前临床治疗中调节肠道菌群的方法,包括益生菌补充、粪便微生物移植、抗菌药物治疗和早期肠内营养等。此外,本文还讨论了上述治疗方法的有效性和安全性,并展望了未来研究的方向,旨在为AP的诊断、治疗及预后评估提供新的视角和策略。通过深入理解肠道菌群与AP的相互作用,有望开发出更为精准和个性化的治疗方案,改善患者的生活质量和临床结局。
Acute pancreatitis(AP)is a severe inflammatory disease characterized by self-digestion of pancreatic tissue and inflammatory responses.Recent studies have revealed a close connection between gut microbiota and AP.The gut microbiota community,a complex ecosystem composed of trillions of microorganisms,is closely associated with various physiological activities of the host,including metabolic processes,immune system regulation,and intestinal structure maintenance.However,in patients with AP,dysbiosis of the gut microbiota are believed to play a key role in the occurrence and progression of the disease.This dysbiosis not only impairs the integrity of the intestinal barrier,but may also exacerbate inflammatory responses through multiple mechanisms,thereby affecting the severity of the disease and patient'clinical prognosis.This article reviews the mechanisms of action of gut microbiota in AP,explores how gut microbiota dysbiosis affects disease progression,and evaluates current clinical treatment methods to regulate intestinal flora,including probiotic supplementation,fecal microbiota transplantation,antibiotic therapy,and early enteral nutrition.In addition,this article discusses the efficacy and safety of the aforementioned therapeutic approaches,and outlines future research directions,aiming to provide novel perspectives and strategies for the diagnosis,treatment and prognostic evaluation of AP.Through in-depth understanding the interaction between gut microbiota and AP,it is expected that more precise and personalized therapeutic regimens will be developed to improve patients'quality of life and clinical outcomes.
作者
郎群
曾钰杰
姚华
戴妮喃
傅小云
付豹
Lang Qun;Zeng Yujie;Yao Hua;Dai Ninan;Fu Xiaoyun;Fu Bao(Department of Critical Care Medicine,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)
出处
《中华危重病急救医学》
北大核心
2025年第9期797-801,共5页
Chinese Critical Care Medicine
基金
国家自然科学基金(82360138)
贵州省卫生健康高质量发展医学科研联合基金项目(2024GZYXKYJJXM0010)。
关键词
急性胰腺炎
肠道菌群
治疗
Acute pancreatitis
Intestinal flora
Treatment
