摘要
目的:制备一种满足人体颈动脉血液动力学参数且含有不同管径的无壁血管超声仿组织材料(TMM),研究其血液动力学。方法:制备具有不同直径的TMM和含有散射颗粒的血液模拟液(BMF),验证其在不同的流速和TMM模体直径条件下血液动力学参数的变化规律。使用多普勒超声测量峰值收缩速度(PSV)、舒张末期速度(EDV)和阻力指数(RI)等关键的血液动力学参数进行分析,并评估其在颈动脉疾病中的临床应用价值。结果:制得的样品其声速为(1506.2±0.1)m/s,衰减为(0.76±0.01)dB/cm,血管直径为4.0和6.0 mm,分别满足临床颈外和颈内动脉正常值范围。测得4.0 mm管腔直径TMM的PSV和EDV与流速呈显著线性相关(R^(2)=0.77, P<0.001;R^(2)=0.74, P=0.001),Pearson相关性分析其呈强正相关(r=0.89, 95%CI:0.82~0.93;r=0.94, 95%CI:0.90~0.97,均P<0.001);6.0 mm管腔直径TMM的PSV和EDV与流速呈显著线性相关(R^(2)=0.70, P=0.001;R^(2)=0.61, P=0.005),Pearson相关性分析其呈强正相关(r=0.86, 95%CI:0.78~0.91;r=0.79,95%CI:0.68~0.87),其数据符合血流动力学参数并遵循血液动力学变化规律。结论:本次研究制备的TMM和BMF可满足临床超声对血液动力学的研究,其材料配比可作其他不同需求的研究后续实验参考。
Objective To fabricate wall-less vascular tissue mimicking materials(TMM)with different tube diameters that match the hemodynamic parameters of human carotid arteries,and to investigate their hemodynamic characteristics.Methods TMM with different diameters and blood mimicking fluids containing scattering particles were fabricated.The variation laws of hemodynamic parameters under different flow velocities and TMM phantom diameters were verified.Key hemodynamic parameters including peak systolic velocity(PSV),end-diastolic velocity(EDV),and resistance index were measured using Doppler ultrasound,and their clinical application value in carotid artery diseases was evaluated.Results The fabricated samples exhibited a sound velocity of(1506.2±0.1)m/s and an attenuation of(0.76±0.01)dB/cm,and the vascular diameters were 4.0 and 6.0 mm,which corresponded to the normal clinical range of the external and internal carotid arteries,respectively.For the 4.0 mm TMM,both PSV and EDV were linearly correlated with flow velocity(R2=0.77,P<0.001;R2=0.74,P=0.001),and Pearson correlation analysis confirmed strong positive correlations(r=0.89,95%CI:0.82-0.93;r=0.94,95%CI:0.90-0.97,all P<0.001).For the 6.0 mm TMM,PSV and EDV also demonstrated significant linear correlations with flow velocity(R2=0.70,P=0.001;R2=0.61,P=0.005),with Pearson correlation analysis revealing strong positive correlations(r=0.86,95%CI:0.78-0.91;r=0.79,95%CI:0.68-0.87).All the data were consistent with hemodynamic parameters and followed the variation law of hemodynamic parameters.Conclusion The fabricated TMM and blood mimicking fluids meet the requirements for clinical ultrasound research on hemodynamics,and their material ratios can be used as a reference for the subsequent researches with diverse objectives.
作者
李虹蔚
吴沛锴
徐子虚
倪昕晔
LI Hongwei;WU Peikai;XU Zixu;NI Xinye(Department of Radiation Oncology,Changzhou No.2 People's Hospital of Nanjing Medical University,Changzhou 213003,China;Jiangsu Province Engineering Research Center of Medical Physics/Medical Physics Research Center of Nanjing Medical University/Key Laboratory of Medical Physics in Changzhou,Changzhou 213003,China;Radiotherapy Center,People's Hospital of Tongjiang County,Bazhong 636700,China;Radiotherapy Center,Sichuan Cancer Hospital,Chengdu 610041,China;Department of Radiation,Heyou International Health System,Foshan 528306,China)
出处
《中国医学物理学杂志》
2025年第11期1507-1513,共7页
Chinese Journal of Medical Physics
基金
国家自然科学基金(62371243)。
关键词
多普勒超声
仿组织材料
血液动力学参数
血液模拟液
Doppler ultrasound
tissue mimicking material
hemodynamic parameter
blood mimicking fluid
