摘要
目的:分析健脾化痰消渴汤辅助卡格列净、二甲双胍治疗肥胖性2型糖尿病(T2DM)患者的临床疗效及对血糖调控、血脂代谢、炎性因子水平的影响。方法:回顾性收集我院2023年4月—2024年2月期间收治的107例肥胖性T2DM患者的临床资料,根据治疗方法不同,将采用卡格列净、二甲双胍治疗的53例患者纳入西药组,采用脾化痰消渴汤辅助卡格列净、二甲双胍治疗的54例患者纳入中药辅助组。治疗3个月后,比较两组临床疗效、治疗前后糖代谢[空腹血糖(FPG)、糖化血红蛋白(HbA1c)、餐后2 h血糖(2 h PG)]、血脂代谢[低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)]、炎性因子[血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-17A、IL-23、IL-6]及治疗期间不良反应发生率。结果:治疗后,中药辅助组总有效率(96.30%)高于西药组(79.25%)(P<0.05);治疗后,中药辅助组FPG、2 h PG、HbA1c、LDL-C、TC、TG均低于西药组,HDL-C水平高于西药组(P<0.05);治疗后,中药辅助组血清IL-1β、hs-CRP、IL-17A、TNF-α、IL-23、IL-6水平均低于西药组(P<0.05);治疗期间,中药辅助组不良反应发生率(12.96%)略高于西药组(9.43%),但组间无明显差异(P>0.05)。结论:健脾化痰消渴汤辅助卡格列净、二甲双胍治疗肥胖性T2DM患者可更好地减轻临床症状,调控血糖水平,改善患者血脂代谢,减轻炎性反应,进而提升临床疗效,且具有较高的用药安全性。
Objective:To analyze the clinical efficacy of Jianpi Huatan Xiaoke decoction assisted with kagligin and metformin in the treatment of obese type 2 diabetes(T2DM)mellitus patients and its influence on blood glucose regulation,blood lipid metabolism and inflammatory factor levels.Methods:Clinical data of 107 obese T2DM patients admitted to our hospital from April 2023 to February 2024 were retrospectively collected.According to different treatment methods,53 patients treated with canagliflozin and metformin were included in the western medicine group,and 54 patients treated with Jianpi Huatan Xiaoke decoction assisted with canagliflozin and metformin were included in the traditional Chinese medicine(TCM)assisted group.After 3 months of treatment,the efficacy,glucose metabolism[fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),2-hour postprandial glucose(2 h PG)],lipid metabolism[low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),triglyceride(TG)],inflammatory factors[serum high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin(IL)-1β,IL-17A,IL-23,IL-6]before and after treatment,incidence of adverse reactions during treatment were compared between the two groups.Results:After treatment,the total effective rate in the TCM assisted group(96.30%)was higher than that in western medicine group(79.25%)(P<0.05).After treatment,the levels of FPG,2 h PG,HbA1c,LDL-C,TC,and TG in the TCM assisted group were lower than those in the western medicine group,while the HDL-C level was higher than that in the western medicine group(P<0.05).After treatment,the levels of IL-1β,hs-CRP,IL-17A,TNF-α,IL-23,and IL-6 in the TCM assisted group were lower than those in the western medicine group(P<0.05).During the treatment,the incidence of adverse reactions in the TCM assisted group(12.96%)was slightly higher than that in the western medicine group(9.43%),but with no significant difference(P>0.05).Conclusion:Jianpi Huatan Xiaoke decoction assisted with kagligin and metformin in the treatment of obese T2DM patients can better alleviate clinical symptoms,regulate blood glucose levels,improve blood lipid metabolism,alleviate inflammatory reactions,and enhance clinical efficacy in obese T2DM patients.It also has high medication safety.
作者
孔姗姗
董捷
方伟
KONG Shanshan;DONG Jie;FANG Wei(Department of Pharmaceutical Equipment,Henan Architectural Hospital,Zhengzhou 450000,China;Department of Geriatric Endocrinology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Department of Internal Medicine,Henan Architectural Hospital,Zhengzhou 450000,China)
出处
《中国民族医药杂志》
2025年第11期1-5,共5页
Journal of Medicine and Pharmacy of Chinese Minorities
关键词
2型糖尿病
肥胖
健脾化痰消渴汤
二甲双胍
卡格列净
Type 2 diabetes mellitus
Obesity
Jianpi Huatan Xiaoke decoction
Metformin
Canagliflozin
