摘要
动脉粥样硬化(atherosclerosis,AS)以气虚为本,痰、瘀为其关键病理产物,痰瘀互结致血脉瘀阻为其主要病理表现。补气、化痰、活血、通络类中药有效单体、药对配伍及复方均可通过抗炎、抗氧化、调节脂代谢、抑制细胞凋亡及改善血管内皮功能等机制干预AS进展,显示出中医药在防治AS方面的显著优势。益气化痰祛瘀法作为早期干预AS的潜在策略,在预防心脑血管疾病等并发症方面具有重要作用。未来应进一步完善中医病证结合动物模型的构建方法与评价体系,结合现代医学研究成果,深入阐释“气虚痰瘀”的机制;同时开展多中心、大样本临床试验,发掘中医证候与现代医学之间的关联规律,以期为AS的早期预防、药物研发、中医诊疗标准体系优化及个体化治疗提供客观依据与新思路。
Atherosclerosis(AS)is fundamentally rooted in Qi deficiency,with phlegm and blood stasis as its key pathological products.The mutual entanglement of phlegm and blood stasis leading to vascular obstruction is its main pathological manifestation.Effective monomers,herbal pairs,and compound prescriptions of traditional Chinese medicine that tonify Qi,resolve phlegm,activate blood,and unblock collaterals can intervene in the progression of AS through mechanisms such as anti-inflammation,antioxidation,regulation of lipid metabolism,inhibition of cell apoptosis,and improvement of vascular endothelial function,demonstrating the significant advantages of traditional Chinese medicine in the prevention and treatment of AS.The method of benefiting Qi,resolving phlegm,and removing stasis serves as a potential strategy for early intervention in AS and plays an important role in preventing complications such as cardiovascular and cerebrovascular diseases.In the future,the methodology and evaluation system for integrating traditional Chinese medicine(TCM)syndromes with animal models should be further improved.By incorporating findings from modern medical research,the mechanisms of"Qi deficiency,Phlegm and blood stasis"should be explored in depth.At the same time,multicenter,large-sample clinical trials should be conducted to uncover the correlation rules between TCM syndromes and modern medicine,aiming to provide objective evidence and new insights for the early prevention of atherosclerosis,drug development,optimization of TCM diagnostic and treatment standards,and individualized therapy.
作者
付晓霄
曹珊
祁祥
FU Xiaoxiao;CAO Shan;QI Xiang(Henan University of Chinese Medicine,Zhengzhou Henan China 450046)
出处
《中医学报》
2025年第12期2588-2594,共7页
Acta Chinese Medicine
基金
河南省自然科学基金项目(242300421295)
崔应民全国名老中医药专家传承工作室建设项目{国中医药人教函〔2022〕75号}
河南省科技攻关项目(232102310434)
河南省中医药科学研究重大专项课题项目(2022ZYZD20)
河南省中医药科学研究重点课题项目(2023ZY1031)。
关键词
动脉粥样硬化
气虚
血瘀
痰浊
“气虚痰瘀”
痰瘀互结
血脉瘀阻
中医药
atherosclerosis
Qi deficiency
blood stasis
Phlegm-Dampness
"Qi deficiency,Phlegm and blood stasis"
mutual entanglement of phlegm and blood stasis
vascular obstruction
traditional Chinese medicine
