摘要
目的分析血府逐瘀汤联合替格瑞洛治疗急性冠状动脉综合征的效果及对患者心功能和内皮功能的影响。方法选取2020年1月至2023年6月于福建中医药大学附属第二人民医院接受治疗的98例急性冠状动脉综合征患者作为研究对象,应用随机数字表法分为对照组与观察组,每组49例。对照组应用替格瑞洛治疗,观察组在对照组基础上应用血府逐瘀汤治疗,比较两组临床疗效、治疗前后心功能指标[肌酸激酶同工酶-MB(creatine kinase isoenzyme-MB,CK-MB)、心肌肌钙蛋白I(cardiac troponin I,cTnI)、B型利尿钠肽(B-type natriuretic peptide,BNP)、N末端B型利尿钠肽原(N-terminal pro-B-type natriuretic peptide,NT-proBNP)、左心室射血分数(left ventricular ejection fraction,LVEF)]和内皮功能指标[血管生成素样蛋白2(angiopoietin-like protein 2,Angptl2)、内皮素-1(endothelin-1,ET-1)和一氧化氮(nitric oxide,NO)]。结果观察组治疗总有效率为93.88%,高于对照组的79.59%(P<0.05)。观察组CK-MB、cTnI、BNP、NT-proBNP、Angptl2、ET-1和NO水平均低于对照组,LVEF高于对照组(P<0.05)。结论血府逐瘀汤联合替格瑞洛治疗急性冠状动脉综合征的效果良好,可改善患者心功能和内皮功能,提高治疗的有效性。
Objective To analyze the efficacy of Xuefu Zhuyu decoction combined with ticagrelor in the treatment of acute coronary syndrome and its impact on cardiac and endothelial function of patients.Methods A total of 98 patients with acute coronary syndrome treated at the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine from January 2020 to June 2023 were selected as the study subjects,and they were divided into the control group and the observation group according to the random number table method,with 49 cases in each group.The control group received ticagrelor treatment,while the observation group received Xuefu Zhuyu decoction on the basis of the control group.The clinical efficacy,cardiac function indicators(creatine kinase isoenzyme-MB[CK-MB],cardiac troponin I[cTnI],B-type natriuretic peptide[BNP],N-terminal pro-B-type natriuretic peptide[NT-proBNP],left ventricular ejection fraction[LVEF])and endothelial function indicators(angiopoietin-like protein 2[Angptl2],endothelin-1[ET-1],and nitric oxide[NO])before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.88%,which was higher than 79.59%in the control group(P<0.05).The levels of CK-MB,cTnI,BNP,NT-proBNP,Angptl2,ET-1 and NO in the observation group were lower than those in the control group,while LVEF was higher than that in the control group(P<0.05).Conclusion Xuefu Zhuyu decoction combined with ticagrelor is effective in the treatment of acute coronary syndrome,which can improve the cardiac function and endothelial function of patients,and improve the effectiveness of treatment.
作者
苏天生
肖章武
SU Tiansheng;XIAO Zhangwu(Department of Emergency,the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian,350003,China)
出处
《当代医学》
2025年第11期142-145,共4页
Contemporary Medicine
基金
福建中医药大学校管科研课题(XB2023021)。
关键词
血府逐瘀汤
替格瑞洛
联合治疗
急性冠状动脉综合征
心功能
内皮功能
Xuefu Zhuyu decoction
Ticagrelor
Combination therapy
Acute coronary syndrome
Cardiac function
Endothelial function
