摘要
阿尔茨海默病(Alzheimer′s Disease,AD)是老年人最常见的痴呆类型,严重威胁老年人健康和生活质量。目前临床上针对AD尚无治愈方法,因此识别可调控风险因素和早期诊断标志物以开展早期预防性和治疗性干预显得至关重要。流行病学研究证据支持感官障碍(如嗅觉、听觉和视觉障碍)与AD密切相关,特别是青中年期感官障碍,且可显著增加AD风险。文章简要综述感官障碍与AD相关联的流行病学研究及潜在的生物学机制,以期引起公众对感官障碍的重视,并为AD的早期识别和预防提供理论依据。
Alzheimer's disease(AD)is the most common type of dementia among older people that significantly affects health and quality of life.Currently,there is no cure,and identifying modifiable risk factors and early diagnostic biomarkers for early preventive and therapeutic interventions becomes crucial.Evidence from epidemiological research has suggested that sensory impairments(e.g.,olfactory,auditory,and visual impairments)are closely linked to AD,especially when sensory impairments occur in young adulthood and middle ages.In this review,we sought to brieflysummarize evidence from epidemiological research that explores the interrelationship between sensory impairments and AD,and further to discuss about the potentialbiological mechanisms underlying their relationships.This review article may help to increase the public awareness of sensory impairments and dementia and to provide a theoretical basis for the early detection and prevention of AD.
作者
公俊杰
董艺
冯建利
张清华
GONG Jun-jie;DONG Yi;FENG Jian-li;ZHANG Qing-hua(Department of Neurology,Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)
出处
《中国实用内科杂志》
北大核心
2025年第10期852-857,共6页
Chinese Journal of Practical Internal Medicine
基金
国家重点研发计划(2017YFC1310100)
山东省博士后创新项目
山东省医药卫生科技项目(202303070279)。
