摘要
目的 探讨内镜下黏膜切除术(EMR)治疗胃肠息肉患者的临床效果及对炎性因子和胃肠激素的影响。方法 选择2023年2月至2025年3月收治的80例胃肠息肉患者,根据术式将其分为对照组(n=40,内镜下电凝电切术)和研究组(n=40,EMR)。比较两组的临床疗效、并发症发生情况及治疗前、后的炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、胃肠激素[胃泌素(GAS)、胃动素(MTL)、血管活性肠肽(VIP)]水平。结果 研究组的完全切除率为95.00%,高于对照组的80.00%(P<0.05);研究组的并发症总发生率为5.00%,低于对照组的22.50%(P<0.05)。治疗后,两组的IL-6、TNF-α水平均升高,但研究组低于对照组(P<0.05)。治疗后,研究组的GAS、MTL水平高于对照组,VIP水平低于对照组(P<0.05)。结论 EMR治疗胃肠息肉患者的临床效果显著,可减轻炎症反应,且对胃肠激素的影响较小。
Objective To investigate the clinical efficacy of endoscopic mucosal resection(EMR)in the treatment of gastrointestinal polyps and its influences on inflammatory factors and gastrointestinal hormones.Methods A total of 80 patients with gastrointestinal polyps admitted from February 2023 to March 2025 were selected and divided into control group(n=40,endoscopic electrocoagulation and electrocision)and study group(n=40,EMR)according to the operation method.The clinical efficacy,complications,and the levels of inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]and gastrointestinal hormones[gastrin(GAS),motilin(MTL),vasoactive intestinal peptide(VIP)]before and after treatment were compared between the two groups.Results The complete resection rate of the study group was 95.00%,which was higher than 80.00%of the control group(P<0.05);the total incidence of complications in the study group was 5.00%,which was lower than 22.50%in the control group(P<0.05).After treatment,the levels of IL-6 and TNF-αin the two groups increased,but those in the study group were lower than the control group(P<0.05).After treatment,the levels of GAS and MTL in the study group were higher than those in the control group,and the level of VIP was lower than that in the control group(P<0.05).Conclusion EMR has a significant clinical effect in the treatment of patients with gastrointestinal polyps,which can reduce the inflammatory response and has less effect on gastrointestinal hormones.
作者
薛建平
XUE Jianping(Gastroenterology Department,the People's Hospital of Tongshan District/No.6 People's Hospital of Xuzhou,Xuzhou 221000,China)
出处
《临床医学研究与实践》
2025年第33期72-75,共4页
Clinical Research and Practice
关键词
内镜下黏膜切除术
胃肠息肉
炎性因子
胃肠激素
endoscopic mucosal resection
gastrointestinal polyp
inflammatory factor
gastrointestinal hormone
