摘要
目的:分析^(18)F-氟脱氧葡萄糖正电子发射断层扫描/计算机体层扫描(^(18)F-FDG PET/CT)的代谢参数在不同组织学类型胸腺上皮肿瘤(TETs)中的鉴别诊断价值。方法:回顾性选取2013年1月至2022年5月在解放军总医院第一医学中心核医学科72例于治疗前行^(18)F-FDG PET/CT检查并经病理诊断为TETs的患者,依据组织学分型将其分为低危胸腺瘤组(9例)、高危胸腺瘤组(15例)和胸腺癌组(48例)。记录患者的临床资料,并根据胸腺瘤外科病理Masaoka-Koga分期对患者进行分期。分别记录病灶的最大标准化摄取值(SUV_(max))、平均标准化摄取值(SUV_(mean))、代谢体积(MTV),病灶糖酵解总量(TLG)以及标准化摄取值比值(SUVR),比较各组代谢参数的差异。通过受试者工作特征(ROC)曲线下面积(AUC),分析^(18)F-FDG PET/CT在不同组织学类型TETs中的诊断效能。结果:3组各项代谢参数分析后发现,高危胸腺瘤组和胸腺癌组的SUV_(max),SUV_(mean)和SUVR均高于低危胸腺瘤组,差异均具有统计学意义(F=10.315、8.336、11.593,P<0.05)。SUVR在胸腺瘤和胸腺癌(AUC为0.864,灵敏感度83.3%,特异性度75.0%)以及高危胸腺瘤和胸腺癌(AUC为0.832,灵敏度为56.3%,特异度为100.0%)的鉴别诊断中具有最高的诊断效能,在低危和高危胸腺瘤,SUVR具有最高的诊断效能(AUC为0.748,灵敏度为80.0%,特异度为66.7%)。结论:^(18)F-FDG PET/CT的代谢参数在鉴别不同组织学分型的TETs具有临床鉴别诊断价值。
Objective:To analyze the differentially diagnostic ability of metabolic parameters of ^(18)F-fluorodeoxyglucose positronemission tomography/computed tomography(^(18)F-FDG PET/CT)in thymic epithelial tumors(TETs)of different histological types.Methods:A total of 72 patients who underwent ^(18)F-FDG PET/CT examination and were confirmed as TETs before treatment at the Department of Nuclear Medicine of the First Medical Center of Chinese PLA General Hospital between January 2013 to May 2022 were analyzed.The patients were divided into thymic tumor with low risk group(9 cases),thymic tumor with high risk group(15 cases)and thymic cancer group(9 cases)according to histological type.The clinical data of patients were recorded,and the patients were staged according to pathological Masaoka-Koga staging of thymic tumor surgery.The maximum standardized uptake value(SUV_(max)),average standardized uptake value(SUV_(mean)),metabolic tumor volume(MTV),total lesion glycolysis(TLG)and standardized uptake value ratio(SUVR)of the lesions were recorded respectively.The differences of metabolic parameters of various group were compared.The area under curve(AUC)value of receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of ^(18)F-FDG PET/CT in TETs of different histological types.Results:The results of analyzing each metabolic parameter of three groups indicated that the SUV_(max),SUV_(mean) and SUVR values of thymic tumor with high risk group and thymic cancer group were significantly higher than them of thymic tumor with low risk group,and the differences were significant(F=10.315,8.336,11.593,P<0.05),respectively.SUVR has the highest diagnostic efficacy in the differential diagnosis for thymic tumor and thymic cancer(AUC:0.864,sensitivity:83.3%,specificity:75.0%),and for thymic tumor with high-risk and thymic cancer(AUC:0.832,sensitivity:56.3%,specificity:100.0%).In addition,SUVR has the highest diagnostic efficacy for thymic tumor with highrisk and thymic tumor with low-risk(AUC:0.748,sensitivity:80.0%,specificity:66.7%).Conclusion:The metabolic parameters of ^(18)F-FDG PET/CT have a certain of differential and diagnostic value in identifying TETs of different histological types.
作者
孙亚兵
徐晓丹
孙树伟
宋敬斌
赵东
王观筠
徐白萱
王瑞民
Sun Yabing;Xu Xiaodan;Sun Shuwei;Song Jingbin;Zhao Dong;Wang Guanyun;Xu Baixuan;Wang Ruimin(Department of Nuclear Medicine,The First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)
出处
《中国医学装备》
2025年第11期65-69,共5页
China Medical Equipment
基金
北京市自然科学基金-海淀原始创新联合基金资助项目(L252051)。
