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SGLT2抑制剂在慢性阻塞性肺疾病中的临床应用价值

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摘要 慢性阻塞性肺疾病(慢阻肺)是全球发病率和致死率较高的疾病之一,给公共卫生带来重大挑战。SGLT2抑制剂(SGLT2i)是一种新型药物,目前广泛用于2型糖尿病、心力衰竭和慢性肾病等疾病治疗。近期SGLT2i在慢阻肺治疗中的潜在价值也逐渐受到关注。本文通过结合现有动物实验和临床研究数据,总结了SGLT2i的抗炎、抗氧化应激、增加促红细胞生成素生成及减少CO_(2)潴留等作用机制,探讨其可能在慢阻肺治疗中的潜在应用前景。尽管目前研究显示SGLT2i在改善慢阻肺症状和预后方面可能具有积极作用,但仍需更多大规模、多中心的随机对照试验来进一步验证其疗效和安全性。未来研究应聚焦于评估SGLT2i对慢阻肺急性加重率、肺功能的影响,并探索生物标志物在疗效预测中的作用,以期为慢阻肺患者提供更有效的治疗方案。
作者 代曼玉 任帅
机构地区 蚌埠医科大学第二附属医院 上海市公共卫生临床中心呼吸科
出处 《临床肺科杂志》 2025年第12期1921-1925,共5页 Journal of Clinical Pulmonary Medicine
关键词 SGLT2i 慢性阻塞性肺疾病 抗炎作用 抗氧化应激 促红细胞生成素 CO_(2)潴留
分类号 R563.9 [医药卫生—呼吸系统]
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临床肺科杂志
2025年 第12期

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