摘要
肿瘤转移作为肿瘤发展进程中的重要阶段,是导致肿瘤患者死亡的主要原因之一.细菌与肿瘤的发生发展密切相关,且在肿瘤转移中扮演着重要的角色.探究细菌对肿瘤转移的作用,对于肿瘤研究至关重要,有助于进一步揭示肿瘤转移的机制,对于研发新的治疗靶点、制定个性化的治疗策略以及判断肿瘤预后具有至关重要的意义.本文回顾了近年来细菌对肿瘤转移影响的研究最新进展,从胞内菌和胞外菌两个方面展开了深入分析,阐明了细菌与肿瘤转移的关系,重点探究了细菌通过直接影响肿瘤细胞以及通过肿瘤微环境的方式对肿瘤转移产生影响的机制.同时,本文也讨论了过往研究中存在的问题,如对细菌来源和定植部位的了解不足,以及研究深度和广度的缺乏.针对这些问题,本文提出了未来研究应该关注的方向,包括选择合适的细菌标志物、扩大细菌种类的研究范围,以及根据细菌特性设计药物靶点和药物载体,探讨了可能的临床转化方案,期望能为肿瘤转移的诊治提供新的思路和方法.
Tumor metastasis stands as a critical juncture in cancer progression,often heralding dire outcomes for patients.Recent research has increasingly spotlighted the intricate interplay between bacteria and tumorigenesis,particularly emphasizing their significant role in fostering tumor metastasis.Unraveling the precise contributions of bacteria to this process holds immense promise for advancing cancer research,offering crucial insights into metastatic mechanisms pivotal for prognostication,innovative therapeutic target development,and the tailoring of personalized treatment strategies.Our review delves into recent strides in understanding how bacteria influence tumor metastasis,scrutinizing their impact from both intracellular and extracellular vantage points.We meticulously examine key milestones in the intersection of bacteria and tumor metastasis,elucidating the complex interrelationships between them.Central to our analysis is a focus on elucidating the diverse mechanisms through which bacteria shape tumor metastasis.Whether through direct interactions with tumor cells or by reshaping the tumor microenvironment,bacteria wield considerable influence.Intracellular bacteria intricately modulate processes such as epithelial-mesenchymal transition,inflammatory responses,and cellular cytoskeletal rearrangements,thereby directly impacting tumor cells and profoundly altering metastatic potential.Moreover,intracellular bacteria exert influence by steering tumor adhesion and immune cell activation,thus reshaping the tumor microenvironment to further drive metastasis.Extracellular bacteria impact tumor cells by triggering DNA damage responses and modulating epithelial-mesenchymal transition dynamics,further skewing the metastatic landscape.Beyond this,extracellular bacteria play a pivotal role in fostering pre-metastatic niche formation and regulating immune cell activity during metastasis,orchestrating their effects through nuanced modulation of the tumor microenvironment.Simultaneously,we critically evaluate past studies,highlighting limitations such as gaps in understanding bacterial sources and colonization sites,as well as deficiencies in research depth and breadth.Addressing these challenges,we advocate several avenues for future research,including the judicious selection of bacterial markers,broadening the research spectrum to encompass diverse bacterial species,and tailoring drug targets and delivery systems to accommodate bacterial nuances.Presently,a substantial body of clinical trials is investigating the inhibitory potential of microbiota modulation on tumor metastasis,ranging from engineered bacterial therapies to fecal microbiota transplantation.We spotlight select exemplary clinical trials showcasing promising outcomes,underpinning our discussion with potential clinical translation schemes.Our aim is to furnish novel insights and approaches for diagnosing and treating tumor metastasis,thereby bridging the chasm between preclinical inquiry and clinical practice to enhance patient outcomes and propel the trajectory of metastasis research forward.
作者
俞婧仪
孟庆娜
陈永霞
季飞洋
王林波
Jingyi Yu;Qingna Meng;Yongxia Chen;Feiyang Ji;Linbo Wang(Department of Surgical Oncology,Sir Run Run Shaw Hospital,Zhejiang University College of Medicine,Hangzhou 310000,China;School of Basic Medical Sciences and Forensic Medicine,Hangzhou Medical College,Hangzhou 310059,China)
出处
《科学通报》
北大核心
2025年第31期5317-5327,共11页
Chinese Science Bulletin
基金
国家自然科学基金(82203610,82272855)资助。
关键词
细菌
肿瘤
转移
肿瘤细胞
肿瘤微环境
Bacteria
tumor
metastasis
tumor cell
tumor microenvironment
