摘要
[目的]探讨双花滋润膏封包疗法治疗血管内皮生长因子受体酪氨酸激酶抑制剂(vascular endothelial growth factor receptor-tyrosine kinase inhibitors,VEGFR-TKIs)所致手足皮肤反应(hand-foot skin reaction,HFSR)的疗效及安全性。[方法]选取2021年10月8日至2024年12月31日在浙江中医药大学附属第一医院就诊的VEGFR-TKIs导致HFSR的肿瘤患者58例,采用随机单盲设计,将患者分为对照组29例和观察组29例。对照组予口服维生素B6联合基质药物封包治疗,观察组则予口服维生素B6联合双花滋润膏封包治疗,两组连续治疗14 d。比较两组患者的HFSR总有效率、疼痛缓解率、生活质量改善情况、不同证型的疗效差异及不良反应情况。[结果]观察组总有效率为89.7%,显著高于对照组的58.6%;观察组疼痛总缓解率为76.9%,显著高于对照组的38.5%;观察组的生活质量提高率为44.8%,显著高于对照组的13.8%,上述差异均有统计学意义(P<0.05)。在湿热瘀阻与热毒蕴肤两种主要证型中,观察组总有效率均高于对照组(P<0.05)。两组均未发生皮肤不良反应及肝肾功能异常。[结论]双花滋润膏封包疗法可有效治疗VEGFR-TKIs所致HFSR,其在总体有效率、疼痛缓解率及生活质量改善方面均优于基质药物封包疗法,且对湿热瘀阻证与热毒蕴肤证患者疗效更为显著。该疗法安全性良好,具有较高的临床应用价值。
[Objective]To investigate the efficacy and safety of Double-Flower Moisturizing Ointment occlusive dressing therapy in treating vascular endothelial growth factor receptor-tyrosine kinase inhibitors(VEGFR-TKIs)induced hand-foot skin reactions(HFSR).[Methods]A total of 58 cancer patients with HFSR induced by VEGFR-TKIs,who were treated at The First Affiliated Hospital of Zhejiang Chinese Medical University from October 8,2021 to December 31,2024,were enrolled in this study.Using a randomized single-blind design,they were assigned to either an observation group(29 cases)or a control group(29 cases).The observation group received oral vitamin B6 combined with Double-Flower Moisturizing Ointment occlusive dressing therapy,while the control group received oral vitamin B6 combined with base ointment occlusive therapy.Both groups were treated for 14 consecutive days.The total effective rate of HFSR management,pain relief rate,quality of life improvement,differences in efficacy between syndrome types and the incidence of adverse reactions were compared between the two groups.[Results]The total effective rate was significantly higher in observation group(89.7%)than in control group(58.6%).The observation group demonstrated a markedly superior overall pain relief rate of 76.9%,which was significantly higher than the 38.5%achieved in control group.Similarly,the quality of life improvement rate in observation group(44.8%)was markedly higher than that in control group(13.8%),with all differences being statistically significant(P<0.05).In the two main syndrome types of damp-heat stagnation and heat-toxicity accumulation on the skin,the observation group exhibited a significantly greater total effective rate compared to control group(P<0.05).No cutaneous adverse reactions or abnormal liver and kidney function were observed in either group.[Conclusion]Double-Flower Moisturizing Ointment occlusive therapy is effective in managing VEGFR-TKIs-induced HFSR.It demonstrates superior outcomes over base ointment occlusive dressing therapy in terms of the overall response rate,pain relief and quality of life improvement,particularly among patients presenting with damp-heat stagnation or heat-toxicity accumulation on the skin.Furthermore,this treatment modality exhibits a favorable safety profile,indicating high clinical application value.
作者
江玲霞
刘振东
JIANG Lingxia;LIU Zhendong(The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine),Hangzhou(310006),China)
出处
《浙江中医药大学学报》
2025年第10期1316-1320,共5页
Journal of Zhejiang Chinese Medical University
基金
浙江省中医药科技计划项目(2022ZB131)。
关键词
酪氨酸激酶抑制剂
手足皮肤反应
肿瘤
双花滋润膏
封包疗法
疼痛
生活质量
中医辨证
tyrosine kinase inhibitors
hand-foot skin reaction
tumor
Double-Flower Moisturizing Ointment
occlusive dressing therapy
pain
quality of life
traditional Chinese medicine syndrome differentiation
