摘要
目的 探讨颅内破裂动脉瘤血管内介入治疗后短暂性脑缺血发作(transient ischemic attack,TIA)的影响因素。方法 回顾性分析224例颅内破裂动脉瘤患者资料,均接受血管内介入治疗;根据治疗后14 d内是否发生TIA分为TIA组(n=71)和无TIA组(n=153)。收集患者临床资料以及血清肿瘤坏死因子-α(tumour necrosis factor-alpha,TNF-α)、白细胞介素(interleukin cell,IL)-6和IL-8水平。多因素Logistic回归分析探究颅内破裂动脉瘤血管内介入治疗后发生TIA的影响因素。结果 治疗后发生TIA 71例,发生率31.70%(71/224)。TIA组和无TIA组年龄、高血压病、吸烟、酗酒、Hunt-Hess分级之间差异具有统计学意义(均P<0.05);TIA组患者治疗前TNF-α、IL-6和IL-8水平显著高于无TIA组(均P<0.05)。多因素Logistic回归分析显示:年龄(OR=1.731,95%CI:1.149~2.607)、高血压病(OR=1.556,95%CI:1.049~2.307)、吸烟(OR=1.982,95%CI:1.069~3.675)、酗酒(OR=2.352,95%CI:1.175~4.707)、Hunt-Hess分级Ⅲ~Ⅳ级(OR=2.327,95%CI:1.120~4.834)、TNF-α(OR=3.154,95%CI:1.188~8.371)是颅内破裂动脉瘤血管内介入治疗后出现TIA的危险因素(均P<0.05)。结论 年龄、高血压病、吸烟、酗酒、Hunt-Hess分级、TNF-α水平均会影响颅内破裂动脉瘤血管内介入治疗后出现TIA,临床上应进行合理干预,戒烟、戒酒,从而减少TIA发生。
Objective To explore the factors influencing transient ischemic attack(TIA)after endovascular interventional therapy for ruptured intracranial aneurysms.Methods The clinical data of 224 patients with ruptured intracranial aneurysms,all of whom received endovascular interventional therapy,were analyzed retrospectively.They were divided into a TIA group(n=71)and a non-TIA group(n=153)based on whether TIA occurred within 14 days after treatment.Clinical data of the patients,as well as their serum levels of tumour necrosis factor-alpha(TNF-α),interleukin(IL)-6,and IL-8,were collected.Multivariate logistic regression analysis was used to investigate the influencing factors for TIA after endovascular interventional therapy for ruptured intracranial aneurysms.Results TIA occurred in 71 patients after treatment,with an incidence rate of 31.70%(71/224).There were statistically significant differences between the TIA group and the non-TIA group in terms of age,hypertension,smoking,alcohol abuse,and Hunt-Hess grade(all P<0.05).The levels of TNF-α,IL-6,and IL-8 before treatment in the TIA group were significantly higher than those in the non-TIA group(all P<0.05).Multivariate logistic regression analysis showed that age(OR=1.731,95%CI:1.149-2.607),hypertension(OR=1.556,95%CI:1.049-2.307),smoking(OR=1.982,95%CI:1.069-3.675),alcohol abuse(OR=2.352,95%CI:1.175-4.707),Hunt-Hess gradeⅢ-Ⅳ(OR=2.327,95%CI:1.120-4.834),and TNF-α(OR=3.154,95%CI:1.188-8.371)were risk factors for TIA after endovascular interventional therapy for ruptured intracranial aneurysms(all P<0.05).Conclusions Age,hypertension,smoking,alcohol abuse,Hunt-Hess grade,and TNF-αlevel can all influence the occurrence of TIA after endovascular interventional therapy for ruptured intracranial aneurysms.Reasonable clinical interventions should be implemented,and individuals should quit smoking and drinking to reduce the occurrence of TIA.
作者
刘新华
邓建中
吕高鹏
LIU Xinhua;DENG Jianzhong;LV Gaopeng(Department of Neurology,Anyang District Hospital of Puyang City,Anyang,Henan 455000,China)
出处
《中国微侵袭神经外科杂志》
2025年第10期589-592,共4页
Chinese Journal of Minimally Invasive Neurosurgery
关键词
颅内动脉瘤
破裂
短暂性脑缺血发作
血管内介入治疗
intracranial aneurysm,ruptured
transient ischemic attack
endovascular intervention
