摘要
脑小血管病(CSVD)是血管性认知障碍重要病理基础,其与肠道菌群失调关联成研究热点。CSVD患者肠道菌群α多样性降低,促炎菌增多、有益菌减少,代谢通路异常。临床及动物实验表明菌群特征与认知功能相关,机制上菌群代谢物参与神经退行性病变。靶向干预策略展现了治疗CSVD潜力,肠道菌群或成早期干预新靶点。
Cerebral small vessel disease(CSVD)serves as a crucial pathological basis for vascular cognitive impairment,and its association with intestinal microbiota dysregulation has become a research hotspot.In CSVD patients,the α-diversity of intestinal microbiota decreases,with an increase in pro-inflammatory bacteria,a reduction in beneficial bacteria,and abnormal metabolic pathways.Clinical and animal experiments have shown that microbiota characteristics are correlated with cognitive function.Mechanistically,microbiota metabolites are involved in neurodegenerative processes.Targeted intervention strategies have demonstrated potential in the treatment of CSVD,suggesting that intestinal microbiota may become a new target for early intervention.
作者
闫芳
王文豪
曹臣
陈晶
YAN Fang;WANG Wenhao;CAO Chen;CHEN Jing(Qingdao Central Hospital,University of Health and Rehabilitation Sciences,Qingdao 266000,Shandong,China)
出处
《中国病原生物学杂志》
北大核心
2025年第12期1668-1670,F0003,共4页
Journal of Pathogen Biology
关键词
脑小血管病
肠道菌群
认知障碍
肠脑轴
干预策略
综述
cerebral small vessel disease
intestinal microbiota
cognitive impairment
gut-brain axis
intervention strategy
review
