摘要
本研究系统分析四川南充地区儿童口腔白色念珠菌的流行病学特征及其与龋病的相关性。从致病机制看,白色念珠菌通过与变异链球菌等致龋菌协同产酸、重塑三维生物膜结构及诱导宿主免疫调节失衡,加速牙体硬组织脱矿进程,可促进龋病发生,其感染与儿童龋患率呈正相关。本次研究为西南地区儿童口腔微生态调控及龋病综合防控提供了重要的理论依据与研究方向。
This study systematically analyzed the epidemiological characteristics of Candida albicans in the oral cavity of children in Nanchong,Sichuan,and its correlation with dental caries.In terms of pathogenic mechanisms,C.albicans accelerates the demineralization of dental hard tissues and promotes caries development by synergistically producing acid with cariogenic bacteria such as Streptococcus mutans,remodeling the three-dimensional biofilm structure,and inducing host immune regulation imbalance.Its infection is positively correlated with the caries prevalence rate in children.This study provides important theoretical basis and research directions for the regulation of oral microecology and comprehensive prevention and control of dental caries in children in southwestern China.
作者
米长江
敬治兴
暴书吟
朱万春
MI Changjiang;JING Zhixing;BAO Shuyin;ZHU Wanchun(Department of Stomatology,North Sichuan Medical College,Nanchong,Sichuan 637000,China;Department of Stomatology,Affiliated Hospital of North Sichuan Medical College)
出处
《中国病原生物学杂志》
北大核心
2025年第12期1653-1656,共4页
Journal of Pathogen Biology
基金
中华口腔医学会西部口腔医学临床科研基金项目(No.CSA-W2020-09)。
关键词
南充地区
白色念珠菌
龋病
综述
Nanchong region
Candida albicans
dental caries
review
