摘要
目的系统比较不同指南中左乙拉西坦(levetiracetam,LEV)的推荐意见,为临床合理用药提供参考。方法本研究通过检索中国知网、万方及MEDLINE等数据库和英国国家卫生与临床优化研究所等常见指南发布组织,纳入不同国家(地区)及组织发表的指南,分析各指南关于LEV在癫痫领域用药方面的差异。结果LEV在各指南中均推荐用于局灶性发作、全面性发作、新生儿惊厥、癫痫持续状态及多种癫痫综合征,但各指南推荐的一线、二线或添加治疗用药建议有所差别。结论本研究对各个国家和地区发表的指南进行系统的整理,有利于临床医务工作者更好地使用指南,为LEV的临床应用提供参考。
OBJECTIVE To compare recommendations on levetiracetam(LEV)across different clinical guidelines systemati-cally,to provide a reference for rational drug use in clinical practice.METHODS A review of guidelines on the use of LEV in the field of epilepsy was conducted by searching databases such as CNKI,Wanfang,MEDLINE,and common guideline publication organizations like the National Institute for Health and Care Excellence(NICE)in the UK.The differences in recommendations on LEV use across various countries,regions,and organizations were analyzed.RESULTS The findings indicated that LEV is recommended for focal seizures,generalized seizures,neonatal seizures,status epilepticus,and various epilepsy syndromes in various guidelines.However,there are differences in the recommendations for first-line,second-line,or add-on therapy among these guidelines.CONCLUSION This study systematically compiles guidelines published by various countries and regions,which will assist healthcare professionals in better utilizing these recommendations and provide a reference for the clinical application of LEV.
作者
孙夕丽
郭宏丽
陈静
卢孝鹏
吴春风
徐进
陈峰
SUN Xili;GUO Hongli;CHEN Jing;LU Xiaopeng;WU Chunfeng;XU Jin;CHEN Feng(Pharmaceutical Sciences Research Center,Department of Pharmacy,Children's Hospital of Nanjing Medical University,Nanjing 210008,China;Department of Neurology,Children's Hospital of Nanjing Medical University,Nanjing 210008,China)
出处
《中国药学杂志》
北大核心
2025年第19期2086-2093,共8页
Chinese Pharmaceutical Journal
基金
中国青年医学创新研究科研课题资助(第八期04号)
南京市卫生科技发展专项资金-医学重点科技发展项目资助(ZKX24039)。
关键词
癫痫
左乙拉西坦
儿童
指南
epilepsy
levetiracetam
children
guideline
