摘要
变应性鼻炎(AR)是儿童最常见的慢性非感染性炎症疾病。中医药采用分期论治与辨证论治相结合的综合体系,在治疗儿童AR方面具有显著优势。本文系统综述了近年来中医药治疗儿童AR的临床治则治法及其作用机制,结果显示中药内治法(小青龙汤、益气脱敏汤等中药方剂或中成药)、中医外治法(揿针、穴位贴敷、推拿及中医鼻疗等)及内外治联合法(中药内服联合穴位贴敷等)在缓解AR患儿临床症状、改善免疫指标、降低复发率等方面展现出显著效果,其作用机制主要与调控Toll样受体/核因子-κB、丝裂原活化蛋白激酶等信号通路有关,从而发挥恢复免疫平衡、缓解炎症反应、抑制细胞焦亡、减少黏液分泌和促进鼻黏膜屏障修复等作用。
Allergic rhinitis(AR)is one of the most common chronic non-infectious inflammatory diseases in children.Traditional Chinese medicine(TCM)employs a comprehensive therapeutic system integrating treatment by stages and syndrome differentiation and treatment,demonstrating significant advantages in the management of pediatric AR.This article systematically reviews the clinical treatment methods and underlying mechanisms of TCM for pediatric AR in recent years.It is found that internal therapies(such as herbal formulas or Chinese patent medicines like Xiaoqinglong decoction,Yiqi tuomin decoction),external therapies(including intradermal needles,acupoint application,tuina,and herbal nasal therapy),as well as combined internal and external approaches(oral herbs combined with acupoint application),have demonstrated significant effects in alleviating clinical symptoms,improving immune indicators,and reducing recurrence rates in children with AR.The underlying mechanisms are primarily associated with the regulation of signaling pathways such as Toll-like receptor/nuclear factor-kappa B and mitogen-activated protein kinase,thereby modulating immune balance,suppressing inflammatory responses,inhibiting pyroptosis,reducing mucus secretion,and promoting nasal mucosal repair.
作者
张中原
曾朔
杨振耀
陈柯言
刘少薇
朱珊
ZHANG Zhongyuan;ZENG Shuo;YANG Zhenyao;CHEN Keyan;LIU Shaowei;ZHU Shan(Pediatric Medical College,Henan University of Chinese Medicine,Zhengzhou 450046,China;Dept.of Pediatrics,the Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450002,China)
出处
《中国药房》
北大核心
2025年第22期2879-2884,共6页
China Pharmacy
基金
河南省自然科学基金项目(No.232300421188)
河南省中医药科学研究专项课题(No.2022ZY1072)
第七批全国老中医药专家学术经验继承工作项目(No.国中医药人教函〔2022〕76号)。
关键词
变应性鼻炎
中医药
分期论治
辨证论治
作用机制
allergic rhinitis
traditional Chinese medicine
treatment by stages
syndrome differentiation and treatment
mechanism of action
