摘要
目的:探讨急性缺血性脑卒中(AIS)病人外周血中性粒细胞(Neu)、高敏C反应蛋白(hs-CRP)与意识障碍的相关性。方法:选择AIS病人228例,按照是否合并房颤和有无意识障碍进行分组,分别比较病人临床资料和Neu计数、Neu百分比、淋巴细胞(Lym)计数、Lym百分比、中性粒细胞与淋巴细胞比值(NLR)、hs-CRP,并分析AIS病人Neu计数、Neu百分比、Lym计数、Lym百分比、NLR、hs-CRP与GCS评分的相关性。结果:意识障碍组病人Neu计数、Neu百分比、hs-CRP均高于无意识障碍组(P<0.01),合并房颤比例高于无意识障碍组(P<0.01)。无房颤AIS病人中,意识障碍病人Neu计数、Neu百分比、hs-CRP均明显高于无意识障碍病人(P<0.01),Lym计数、Lym百分比均明显低于无意识障碍病人(P<0.01)。在合并和不合并房颤AIS病人中,不同意识障碍程度病人Neu计数、Neu百分比、hs-CRP间差异均有统计学意义(P<0.05~P<0.01),且Neu计数、Neu百分比、hs-CRP与GCS评分均呈负相关关系(P<0.05)。结论:AIS意识障碍病人Neu计数、Neu百分比、hs-CRP均升高,Neu计数、Neu百分比、hs-CRP与GCS评分均呈负相关关系。
Objective:To investigate the correlations between the neutrophils(Neu),hgh sensitivity C-reactive protein(hs-CRP)and consciousness disturbance in patients with acute ischemic stroke(AIS).Methods:Two hundred and twenty-eight patients with AIS were selected.The clinical data and Neu count,Neu percentage,lymphocyte(Lym)count,Lym percentage,neutrophil to lymphocyte ratio(NLR)and hs-CRP were compared between consciousness disturbance group and non-consciousness disturbance group.The correlations between the Neu count,Neu percentage,Lym count,Lym percentage,NLR,hs-CRP and GCS score in AIS patients were analyzed.Results:The Neu count,Neu percentage and hs-CRP in the consciousness disturbance group were higher than those in non-consciousness disturbance group(P<0.01),and the proportion of patients with atrial fibrillation in the consciousness disturbance group was higher than that in non-consciousness disturbance group(P<0.01).In AIS patients without atrial fibrillation,the Neu count,Neu percentage and hs-CRP in patients with consciousness disturbance were significantly higher than those without consciousness disturbance(P<0.01),and the Lym count and percentage in patients with consciousness disturbance were significantly lower than those without consciousness disturbance(P<0.01).Among AIS patients with and without AIS,the differences of Neu count,Neu percentage and hs-CRP among patients with different degree of consciousness disturbance were statistically significant(P<0.05 to P<0.01).Among AIS patients with and without atrial fibrillation,the Neu count,Neu percentage and hs-CRP were negatively correlated with GCS score(P<0.05).Conclusions:The Neu count,Neu percentage and hs-CRP in AIS patients with consciousness disturbance increase,and the Neu count,Neu percentage and hs-CRP are negatively correlated with GCS score.
作者
黄海梅
余丹
刘春苗
林夏妃
HUANG Haimei;YU Dan;LIU Chunmiao;LIN Xiafei(Department of Neurology,Haikou People's Hospital,Haikou Hainan 570226,China;Department of Rehabilitation Medicine,Haikou People's Hospital,Haikou Hainan 570226,China)
出处
《蚌埠医科大学学报》
2025年第10期1417-1420,1424,共5页
Journal of Bengbu Medical University
基金
海南省卫生健康行业科研项目(20A200061)。
关键词
急性缺血性脑卒中
意识障碍
中性粒细胞
高敏C反应蛋白
房颤
acute ischemic stroke
consciousness disturbance
neutrophils
high sensitivity C-reactive protein
atrial fibrillation
