摘要
背景:生物募集组织修复材料通过精准调控细胞迁移、分化,促进组织修复与再生,从而推动再生医学应用。目的:总结生物募集组织修复材料在再生医学领域中的研究现状。方法:由第一作者检索中国知网、PubMed数据库中收录的文章,文献检索时限为2010年1月至2025年3月,以“生物材料,募集,修复,成骨,软骨,血管”为中文检索词,以“biomaterials,recruitment,repair,osteogenesis,cartilage,vascularization”为英文检索词,最终选取符合标准的90篇文献进行综述。结果与结论:在组织修复领域内,生物募集组织修复材料的核心优势在于精确控制细胞迁移、增殖行为及生长因子活性,这类材料优化生长因子的时空释放模式与信号通路激活效率,以及创面定向迁移的速度,相比传统材料可显著提升组织再生速率。在设计层面,调整材料的亲疏水性、降解速率及力学模量,可确保植入物与组织的力学适配性及安全降解。在功能化方面,采用精氨酸-甘氨酸-天冬氨酸肽、肝素等亲和分子进行表面修饰,赋予材料特异性结合整合素受体或固定生长因子的能力,直接增强靶细胞黏附效率并延长生长因子局部作用时间。凭借可控的降解-再生匹配性、高效的空间引导能力及低免疫原性,生物募集组织修复材料为骨缺损、血管再生等难题提供了新工具,并拓展至神经、软骨等复杂组织再生领域。
BACKGROUND:Recruitable tissue repair biomaterials promote the application of regenerative medicine by precisely regulating cell migration,differentiation,and facilitating tissue repair and regeneration.OBJECTIVE:To summarize the current research status of recruitable tissue repair biomaterials in the field of regenerative medicine.METHODS:The first author meticulously retrieved articles from the China National Knowledge Infrastructure(CNKI)and PubMed databases,covering the time span from January 2010 to March 2025.The search terms employed were“biomaterials,recruitment,repair,osteogenesis,cartilage,vascularization”in Chinese and English.After rigorous screening,90 articles that fulfilled the predefined criteria were included in this review.RESULTS AND CONCLUSION:In the field of tissue repair,recruitable tissue repair biomaterials have shown significant value due to their ability to precisely regulate cell migration,proliferation behavior and growth factor activity.By optimizing the spatiotemporal release pattern of growth factors and the activation efficiency of signal pathways,these materials can accelerate directional migration of wound surfaces,thereby promoting tissue regeneration compared with traditional materials.At the design level,adjusting the hydrophilicity,degradation rate and mechanical modulus of the material can ensure the mechanical compatibility and safe degradation of the implant and tissue.In terms of functionalization,surface modification with affinity molecules such as arginine-glycine-aspartic acid peptides and heparin can give the material the ability to specifically bind to integrin receptors or fix growth factors,directly enhancing the target cell adhesion efficiency and prolonging the local action time of growth factors.With controllable degradation-regeneration matching,efficient spatial guidance ability and low immunogenicity,recruitable tissue repair biomaterials provide new tools for difficult problems such as bone defects and vascular regeneration,and expand to the field of complex tissue regeneration such as nerves and cartilage.
作者
刁有录
高佳
潘国庆
Diao Youlu;Gao Jia;Pan Guoqing(Institue for Advanced Materials,School of Materials Science and Engineering,Jiangsu University,Zhenjiang 212013,Jiangsu Province,China)
出处
《中国组织工程研究》
北大核心
2026年第20期5270-5281,共12页
Chinese Journal of Tissue Engineering Research
基金
江苏省研究生科研与实践创新计划项目(KYCX24_3950),项目负责人:刁有录
国家自然科学基金项目(32401113,32222041),项目负责人:高佳、潘国庆
中国博士后科学基金面上资助项目(2024M751193),项目负责人:高佳
国家资助博士后研究人员计划项目(GZC20240617),项目负责人:高佳
江苏省卓越博士后资助计划项目(2024ZB698),项目负责人:高佳
江苏省高等学校基础科学(自然科学)研究面上项目(24KJB430013),项目负责人:高佳。
关键词
可募集生物材料
细胞招募
生长因子识别
细胞调控
组织修复
生物材料
recruitable biomaterial
cell recruitment
growth factor recognition
cellular regulation
tissue repair
biomaterial
