摘要
目的分析溃疡性结肠炎(ulcerative colitis,UC)患者血清三结构域家族蛋白22(serum tripartite motif containing protein 22,TRIM22)、胰高血糖素样肽2(glucagon-like peptide 2,GLP-2)与炎症因子和黏膜愈合的关系。方法选取2022年9月至2024年6月入住我院UC患者120例为观察组。同期选取在我院进行正常体检的健康人员120名为对照组。依照UC患者病情严重程度将其分为轻度组69例、中度组40例、重度组11例。依照Mayo内镜评分将患者分为愈合良好组75例,愈合不良组45例。检测血清TRIM22、GLP-2、炎症因子表达水平及黏膜愈合程度,分析UC患者血清TRIM22、GLP-2与炎症因子和黏膜愈合的关系。结果与对照组对比,观察组UC患者血清TRIM22表达水平升高(P<0.05),GLP-2表达水平降低(P<0.05)。与轻度组对比,中度组、重度组UC患者血清TRIM22表达水平升高(P<0.05),GLP-2表达水平降低(P<0.05)。与对照组对比,观察组UC患者血清中CRP、IL-1β、IL-17表达水平升高(P<0.05)。与轻度组对比,中度组、重度组UC患者血清中CRP、IL-1β、IL-17表达水平升高(P<0.05)。与愈合良好组对比,愈合不良组TRIM22表达水平升高,GLP-2表达水平降低(P<0.05)。相关性分析显示,TRIM22与黏膜愈合程度、CRP、IL-1β、IL-17呈正相关(P<0.05),GLP-2与黏膜愈合程度、CRP、IL-1β、IL-17呈负相关(P<0.05)。与TRIM22、GLP-2单项诊断相比,联合检测对UC的诊断价值较高(P<0.05)。结论UC患者血清中的TRIM22表达水平升高,GLP-2表达水平降低,其水平的异常升高或降低是UC疾病发生、发展的主要风险预测因子,可能与病情的预测、发展以及炎症因子和黏膜愈合之间存在一定关联。
Objective To analyze the relationship between serum tripartite motif containing protein 22(TRIM22),glucagon-like peptide 2(GLP-2),inflammatory factors and mucosal healing in ulcerative colitis(UC)patients.Methods From Sep.2022 to Jun.2024,120 UC patients were selected in our hospital as the observation group.During the same period,120 healthy people with normal physical examination in our hospital were selected as the control group.According to the severity of the disease,69 patients were divided into mild group,40 into moderate group and 11 in severe group.The patients were divided into 75 patients in the good healing group and 45 patients in the poor healing group.Serum expression levels of TRIM22,GLP-2 and inflammatory factors and the degree of mucosal healing were tested,and the relationship between serum TRIM22 and GLP-2 and inflammatory factors and mucosal healing was analyzed in UC patients.Results Compared with the control group,serum TRIM22 expression increased and GLP-2 expression decreased in the observation group(P<0.05).Compared with mild groups,serum TRIM22 was increased in moderate and severe patients(P<0.05)and GLP-2 was decreased(P<0.05).Compared with the control group,the expression levels of CRP,IL-1βand IL-17 in the serum of UC patients in the observation group were increased(P<0.05).Compared with mild group,CRP,IL-1βand IL-17 were increased in moderate and severe group(P<0.05).Compared with the well-healing group,TRIM22 expression was increased and GLP-2 expression was decreased in the poor-healing group(P<0.05).For the correlation analysis,there was a positive correlation between TRIM22 and the degree of mucosal healing,CRP,IL-1β,and IL-17(P<0.05),and a negative correlation between GLP-2 and mucosal healing,CRP,IL-1β,and IL-17(P<0.05).Compared with the single diagnosis of TRIM22 and GLP-2,the combined test had a higher diagnostic value of UC(P<0.05).Conclusion The increased expression level of TRIM22 in the serum and the decreased expression level of GLP-2,and the abnormal increase or decrease of which are the main risk predictor of the occurrence and development of ulcerative colitis disease,which may have some association with the prediction of the disease,the development,and inflammatory factors and mucosal healing.
作者
马曦
李志晋
李万狮
徐楚欣
许永春
MA Xi;LI Zhijin;LI Wanshi;XU Chuxin;XU Yongchun(Department of Gastroenterology,the 908th Hospital of Joint Logistics Support Force,Nanchang 330001,China)
出处
《胃肠病学和肝病学杂志》
2025年第11期1606-1610,共5页
Chinese Journal of Gastroenterology and Hepatology
基金
江西省中医药管理局科技计划项目(2023B0263)。
