摘要
细胞外囊泡(extracellular vesicles,EVs)是由细胞释放到细胞外微环境的膜包被的颗粒。在神经系统中,EVs是介导生物分子运输和细胞间通讯的关键载体,它们深度参与调控生理稳态与病理级联反应,同时在疾病诊断与治疗领域展现出重要应用价值。本文系统综述了神经元与胶质细胞源性EVs的功能异质性及研究进展,以期为阐明EVs在神经系统的多样化角色提供理论依据。
Extracellular vesicles(EVs)are membrane-bound particles released by cells into the extracellular microenvironment.In the nervous system,EVs serve as critical mediators of biomolecule trafficking and intercellular communication.These vesicles are deeply involved in orchestrating physiological homeostasis and pathological cascades,while demonstrating significant potential for therapeutic and diagnostic applications.In this review,we systematically summarize the functional heterogeneity and research advances in neuron-and glial cell-derived EVs,aiming to provide a theoretical basis for understanding the diverse roles of EVs in the nervous system.
作者
陈佳强
丁梅
Jiaqiang Chen;Mei Ding(Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100093,China)
出处
《遗传》
北大核心
2025年第11期1197-1213,共17页
Hereditas(Beijing)
基金
国家自然科学基金项目(编号:31921002)资助。
