摘要
烟雾病是一种特殊的脑血管疾病,特征是颈内动脉终末部及其主要分支进行性狭窄,这些变化导致慢性脑血管闭塞,并形成一个异常的血管网络。既往研究发现,烟雾病的发病与遗传、炎症、免疫反应等因素有关,但其病因和发病机制尚不清楚。近年来在炎症方面对烟雾病发病机制的研究取得较大突破,炎症因子和炎症相关蛋白在烟雾病的发病中有重要作用,自身免疫性疾病介导的炎症反应也能促进烟雾病的发病。然而,尽管在炎症与烟雾病关系的研究中取得了一定进展,但是目前针对炎症如何具体推动烟雾病发展的机制,尚未形成系统性框架,相关研究仍处于零散探索阶段。现有文献多聚焦于单一炎症因子或局部病理过程,缺乏对炎症在烟雾病全病程中的动态作用的全面剖析。本综述通过对数据库现有的关于炎症对烟雾病发病作用的文献进行检索,并归纳与总结,旨在深入了解炎症因素对烟雾病发病机制的影响,进而为烟雾病的综合治疗策略提供理论支持和实践指导。
Moyamoya disease is a specific cerebrovascular disease characterized by progressive narrowing of the terminal part of the internal carotid artery and its major branches,and these changes lead to chronic cerebrovascular occlusion and the formation of an abnormal vascular network.Previous studies have found that the pathogenesis of moyamoya disease is related to genetics,inflammation,immune response and other factors,but its etiology and pathogenesis are still unclear.In recent years,great breakthroughs have been made in the study of the pathogenesis of moyamoya disease in the aspect of inflammation.Inflammatory factors and inflammationrelated proteins play an important role in the pathogenesis of moyamoya disease,and the inflammatory response mediated by autoimmune diseases can also promote the pathogenesis of moyamoya disease.However,although some progress has been made in the study of the relationship between inflammation and moyamoya disease,no systematic framework has been formed for the mechanism of how inflammation specifically promotes the development of moyamoya disease,and relevant studies are still in the stage of scattered exploration.Most of the existing literatures focus on single inflammatory factors or local pathological processes,and lack a comprehensive analysis of the dynamic role of inflammation in the whole course of moyamoya disease.By searching the existing literature on the role of inflammation on the pathogenesis of moyamoya disease in the database,and comprehensively summarizing the literature,this review aims to deeply understand the influence of inflammatory factors on the pathogenesis of moyamoya disease,and then provide theoretical support and practical guidance for the comprehensive treatment strategy of moyamoya disease.
作者
黄朝觉
陈雨阳
梁惠
刘畅
冯大勤
HUANG Chaojue;CHEN Yuyang;LIANG Hui;LIU Chang;FENG Daqin(Department of Neurosurgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;The First Clinical College of Medicine,Guangxi Medical University,Nanning 530021,China)
出处
《广西医科大学学报》
2025年第5期761-769,共9页
Journal of Guangxi Medical University
基金
广西自然科学基金青年项目(No.2023GXNSFBA026092)
广西自然科学基金面上项目(No.2024GXNSFAA010100)
广西重点研发计划项目(No.2023AB22116)
国家自然科学基金地区项目(No.82260554)。
关键词
烟雾病
抗炎细胞因子
促炎细胞因子
环脂蛋白213
小窝蛋白-1
血管内皮生长因子
moyamoya disease
anti-inflammatory cytokines
proinflammatory cytokines
ring finger protein 213
caveolin-1
vascular endothelial growth factor
