摘要
富含亮氨酸重复序列(LRR)是一种常见的蛋白结构, 存在于多种蛋白质中, 对维持这些蛋白的生物学功能具有至关重要的作用。眼组织是重要的感官系统, 并通过视神经与神经系统相连, 已有相关研究证实眼组织中的多种蛋白, 如富含亮氨酸的小蛋白聚糖、角蛋白聚糖、富含亮氨酸重复序列8、NOD样受体热蛋白结构域相关蛋白3和NYX等富含LRR序列, 直接或者间接参与近视、视网膜疾病、青光眼、葡萄膜炎、夜盲、角膜病和眼部纤毛病变等多种眼病的发生。本文以LRR相关蛋白在眼科疾病中的功能研究为核心进行回顾性阐述, 希望通过关注对眼部发育至关重要的LRR相关蛋白, 为各种眼科疾病的诊断和治疗提供新思路。
Leucine rich repeat(LRR)is a common protein structure that exists in many kinds of proteins and plays a crucial role in maintaining the biological function of these proteins.Eye tissue is an important sensory system and connects with nervous system through the optic nerve.There are relevant studies to confirm that a variety of LRR proteins in eye tissue,such as small leucine-rich proteoglycans,keratocan,leucines-rich repeat-containing 8,NOD-like receptor thermal protein domain associated protein 3 and NYX,which take part in multiple ocular diseases including myopia,retinal diseases,glaucoma,uveitis,night blindness,corneal diseases and eye fibropathy.This article focuses on the functional research of LRR-related proteins in ophthalmic diseases.The hope is that focusing on LRR-related proteins crucial to ocular development will provide new ideas for the diagnosis and treatment of various ophthalmic diseases.
作者
魏堯(综述)
蒋灵晰
石毅(审校)
Wei Yao;Jiang Lingxi;Shi Yi(Genetic Diseases Key Laboratory of Sichuan Province,Department of Laboratory Medicine,Sichuan Provincial People's Hospital,Chengdu 610072,China)
出处
《中华实验眼科杂志(中英文)》
北大核心
2025年第10期951-957,共7页
Chinese Journal Of Experimental Ophthalmology
基金
国家自然科学基金(82571261)。
