摘要
衰老是一个由多种因素引发的复杂过程,表现为生理及行为能力的逐渐减退。在各个器官中,大脑尤其易受衰老影响。脑衰老不仅造成老年人认知能力的下降,还会增加神经退行疾病的风险,导致老年人生活质量下降及社会老龄化负担增加。因此,有必要对生理性和病理性脑衰老的机制及生物标志物进行充分研究,从而及早对脑衰老进行预防、监测和干预。线粒体在生理性和病理性脑衰老过程中发挥关键作用,线粒体相关的脑衰老机制和生物标志物是脑衰老研究的重要方向。文章综述了生理性与病理性脑衰老的主要表现和机制上的区别和联系,总结了线粒体在脑衰老过程中的作用机制,线粒体相关的脑衰老生物标志物,以及针对线粒体的健康衰老干预措施。
Aging is a complex process triggered by multiple factors,characterized by the gradual decline of physiological and behavioral capabilities.Among various organs,the brain is particularly susceptible to aging effects.Brain aging not only leads to cognitive decline in the elderly but also increases the risk of neurodegenerative diseases,resulting in reduced quality of life and increased social aging burdens.Therefore,it is essential to thoroughly investigate the mechanisms and biomarkers of both physiological and pathological brain aging to enable early prevention,monitoring,and intervention.Mitochondria play a crucial role in both physiological and pathological brain aging processes,making mitochondrial-related mechanisms and biomarkers key research directions in this field.This article reviews the main manifestations and mechanistic differences between physiological and pathological brain aging,summarizes mitochondrial mechanisms in brain aging,identifies mitochondrial-associated biomarkers,and proposes health-promoting,mitochondria-targeting interventions.
作者
王雪哲
梁峻菡
于庚辰
陈姿喧(综述)
邓玉林(审校)
WANG Xuezhe;LIANG Junhan;YU Gengchen;CHEN Zixuan;DENG Yulin(School of Medical Technology,Beijing Institute of Technology,Beijing 100081,China)
出处
《国际检验医学杂志》
2025年第21期2638-2647,共10页
International Journal of Laboratory Medicine
