摘要
目的探讨红细胞分布宽度(red blood cell distribution width,RDW)与血清神经元特异性烯醇化酶(neuron specifi c enolase,NSE)在结肠恶性肿瘤中的诊断价值。方法选取新疆医科大学第五附属医院2018年1月至2021年1月临床明确诊断为结肠癌患者154例(结肠癌组)和健康者150例(对照组),比较两组患者的血常规指标,包括红细胞计数、血小板计数、淋巴细胞比值、RDW,以及肿瘤标志物,包括癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原125(carbohydrate antigen 125,CA125)、糖类抗原19-9(carbohydrate antigen 125,CA19-9)、NSE水平,并比较结肠癌患者的RDW、NSE水平。通过应用受试者操作特征(receiver operating characteristic,ROC)曲线分析RDW、NSE、CEA、CA19-9对结肠癌的诊断价值。结果血常规中红细胞计数、淋巴细胞比值、RDW,肿瘤标志物中NSE、CEA、CA125、CA19-9与对照组比较差异有显著性,血清RDW阳性表达与肿瘤病理分期和是否发生淋巴结转移有显著相关性,通过ROC曲线得出RDW、NSE及其联合CEA、CA19-9对结肠癌具有较高诊断价值。结论RDW、NSE水平升高与结肠癌发生发展可能存在密切关系,两者可能成为结肠癌早期诊断及病情判断的一个重要指标。
Objective To explore the diagnostic value of red blood cell distribution width(RDW)and serum neuron specific enolase(NSE)in colon malignant tumors.Method 154 cases of patients with a clear clinical diagnosis of colon cancer(colon cancer group)and 150 cases of healthy people(control group)were selected from The Fifth Affiliated Hospital of Xinjiang Medical University from 2018 January to 2021 January,and the blood routine indexes of the two groups were compared,including red blood cell(RBC),platelet(PLT),lymphocyte ratio(LY%),RDW and tumor We compared the levels of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA-125),carbohydrate antigen 125(CA-199),and NSE in colon cancer patients with diff erent clinical data.RDW and NSE levels in colon cancer patients with diff erent clinical data.The diagnostic value of RDW,NSE,CEA and CA19-9 for colon cancer was analyzed by applying receiver operating characteristic(ROC)curve.Result RBC,LY%,RDW in blood routine,NSE,CEA,CA125,CA19-9 in tumor markers were statistically significant compared with the control group,and there was a significant correlation between the positive expression of serum RDW and the pathological stage of the tumor and whether lymph node metastasis had occurred,and it was concluded that RDW,NSE and its combination with CEA and CA19-9 had high diagnostic value in colon cancer by ROC curve.The ROC curve showed that RDW,NSE and their combination with CEA and CA19-9 had high diagnostic value for colon cancer.Conclusion Elevated levels of RDW and NSE may have a close relationship with the development of colon cancer,and both of them may become an important indicator for the early diagnosis and judgment of colon cancer.
作者
周博
苏洪德
郑广涛
张军翔
张胜飞
赵传魁
Zhou Bo;Su Hongde;Zheng Guangtao;Zhang Junxiang;Zhang Shengfei;Zhao Chuankui(Hepatobiliary Pancreatic Surgery Department of The Fifth Affiliated Hospital of Xinjiang Medical University,Xinjiang Urumqi 830000,China;Gastroenterology Department of Xinjiang Production and Construction Corps Hospital,Xinjiang Urumqi 830000,China)
出处
《临床普外科电子杂志》
2025年第3期18-23,共6页
Journal of General Surgery for Clinicians(Electronic Version)
