摘要
In this paper,we demonstrate the application of Metal-Assisted and Microwave-Accelerated Evaporative Crystallization(MA-MAEC)technique to rapid and selective crystallization of a small drug compound.i.e.acetaminophen.Subsequent characterization of the crystals by optical microscopy,powder X-ray diffraction(PXRD)and Raman spectroscopy showed quantitatively selective growth of different crystal forms at various experimental conditions.Acetaminophen crystals were grown predominantly as Form I(99%)on blank glass slides at room temperature.Form II crystals with 39%purity grown on SIFs using microwave energy.
基金
supported by Award Number 5-K25EB007565-05 from the National Institute of Biomedical Imaging and Bioengineering.
