摘要
The present study was aimed to fabricate Curcumin loaded Eudragit E 100 polymeric nanoparticles and to study the effect of various manufacturing parameters on the average particle size,span,uniformity and surface area of the prepared polymeric nanoparticles by utilizing Plackett-Burman experimental designs.Curcumin loaded Eudragit E 100 nanoparticles were prepared by nanoprecipitation method and characterized using particle size analyser.Plackett-Burman design was implemented to study the influence of eight independent variables on three dependent variables.Twelve th th experimental trials involving 8 independent variables at higher and lower levels were generated by Design-Expert.Out of 12 trials,4 and 9 trails were within the acceptable limits.Least average particle size can be obtained by increasing the concentration of poloxamer 188,increasing the volume of aqueous phase,increasing the sonication duration and decreasing the ethanol concentration.Similarly,span less than 1 can be obtained by increasing the concentration of poloxamer 188,increasing the sonication duration and decreasing the ethanol concentration.However,uniformity can be increased decreasing the ethanol concentration.Higher surface area can be obtained by increasing the concentration of Eudragit E 100,poloxamer 188 and increasing the volume of the aqueous phase.
