摘要
目的本研究旨在评估液基薄层细胞学检查(TCT)结合HPV基因芯片法(HPV-DNA)检测对宫颈上皮内瘤变(CIN)的诊断效果,以提升宫颈癌前病变的早期筛查能力和诊断准确性。方法收集我院就诊64例具有宫颈病变高风险的患者,将其随机分为实验组与对照组。实验组接受TCT联合HPV-DNA检测,对照组仅进行TCT检查。通过阴道镜下病理活检结果作为最终确诊标准,分别对比两组的灵敏度、特异度、阳性预测值及阴性预测值,评价其诊断效能。结果实验组(TCT联合HPV-DNA检测)的灵敏度为92.5%,特异度为85.3%,阳性预测值为90.6%,阴性预测值为87.1%;对照组(仅TCT检测)的灵敏度为75.0%,特异度为70.0%,阳性预测值为78.1%,阴性预测值为66.7%。实验组的CIN检出率为87.5%,显著高于对照组的65.6%(P<0.05)。结论液基薄层细胞学(TCT)检查联合HPV基因芯片法检测在宫颈上皮内瘤变的诊断中具有较高的灵敏度和特异度,优于单独的液基细胞学(TCT)检测方法,能够显著提高宫颈上皮内瘤变(CIN)的检出率,适用于宫颈癌前病变的早期筛查,具有较高的临床推广价值。
Objective The purpose of this study is to evaluate the diagnostic effect of liquid-based thin-layer cytological examination(TCT)combined with HPV gene chip detection on cervical intraepithelial neoplasia(CIN),so as to improve the early screening ability and diagnostic accuracy of cervical precancerous lesions.Methods 64 patients with high risk of cervical lesions were randomly divided into experimental group and control group.The experimental group received TCT combined with HPV-DNA test,while the control group underwent TCT test only.The diagnostic efficacy of the two groups was evaluated by comparing the sensitivity,specificity,positive predictive value and negative predictive value of the colposcopy pathological biopsy results as the final criterion for diagnosis.Results In the experimental group(TCT combined with HPV-DNA test),sensitivity was 92.5%,sensitivity was 85.3%,positive predictive value 80.6%,and negative predictive value 87.1%;in the control group(TCT only),sensitivity was 75.0.0%,positive 78.1%,and negative predictive value 66.7%.The CIN detection rate in the experimental group was 87.5%,significantly higher than the 65.6%in the control group(P<0.05).Conclusions liquid based thin-layer cytology(TCT)examination combined with HPV gene chip detection in cervical intraepithelial neoplasia diagnosis has high sensitivity and specificity,is better than separate liquid based cytology(TCT)detection method,can significantly improve the detection rate of cervical intraepithelial neoplasia(CIN),is suitable for early screening of cervical cancer lesions,has a high clinical promotion value.
作者
张琦
ZHANG Qi(Harbin 242 Hospital,Harbin,Heilongjiang,150066)
出处
《航空航天医学杂志》
2025年第11期1288-1290,共3页
Journal of Aerospace medicine
关键词
液基薄层细胞学检查
HPV-DNA检测
宫颈上皮内瘤变
诊断效能
宫颈癌筛查
liquid-based thin-layer cytology
HPV-DNA testing
cervical intraepithelial neoplasia
diagnostic efficacy
cervical cancer screening
