摘要
星形胶质细胞作为中枢神经系统中最主要的胶质细胞之一,在脑内执行广泛的内稳态功能。若星形胶质细胞发生数量减少或者功能障碍,则神经内稳态功能受损,从而导致抑郁症的发生发展。针刺治疗抑郁症疗效确切,本文以近年来针刺调控星形胶质细胞抗抑郁的大量文献为基础,从改善星形胶质细胞的形态和数量、调节星形胶质细胞-神经元相互作用、调节星形胶质细胞-小胶质细胞间串扰3个方面综述了针刺抗抑郁的作用机制,并提出了未来研究的方向,以期为靶向调控星形胶质细胞治疗抑郁症提供新思路。
Astrocytes,as one of the major glial cells in the central nervous system,performa wide range of homeostatic functions in the brain.A reduction in the number or dysfunction of astrocytes impairs neural homeostatic functions,thereby contributing to the occurrence and development of depression.Acupuncture has a proven efficacy in treating depression.Based on a large number of recent studies on the regulation of astrocytes by acupuncture for antidepressant effects,this paper reviews the mechanisms of acupuncture in treating depression fromthree aspects:improving the morphology and quantity of astrocytes,regulating astrocyte-neuron interactions,and modulating astrocyte-microglia crosstalk,and proposes directions for future research.It is expected to provide new insights for the targeted regulation of astrocytes in the treatment of depression.
作者
徐宁
黄桃
王珑
XU Ning;HUANG Tao;WANG Long(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040;Luoyang Town Health Center of Quanzhou Taiwan Residents Business Investment Zone,Quanzhou 362100,Fujian Province)
出处
《针刺研究》
北大核心
2025年第10期1220-1226,共7页
Acupuncture Research
基金
黑龙江省自然科学基金项目(No.LH2022H082)。
关键词
抑郁
针刺
星形胶质细胞
机制
Depression
Acupuncture
Astrocytes
Mechanism
