摘要
目的:对乌灵胶囊辅助治疗精神分裂症的疗效及安全性进行系统评价。方法:计算机检索中国生物医学文献数据库、中国知网、万方数据库、维普数据库、PubMed、Web of Science、the Cochrane Library、Embase、OVID、CINAHL、Scopus、APA PsycInfo等数据库,检索时限为建库至2024年4月,纳入乌灵胶囊辅助治疗精神分裂症的临床随机对照试验(对照组采用常规基础治疗,研究组在对照组的基础上联合应用乌灵胶囊)。按照纳入与排除标准筛选文献、提取资料并进行质量评价后,采用RevMan 5.4软件进行Meta分析。结果:共纳入8篇文献,包含研究对象836例。Meta分析结果显示,联合应用乌灵胶囊降低阳性与阴性症状量表(PANSS)总分(MD=-8.33,95%CI=-15.75~-0.90,P=0.03)、PANSS阴性症状评分(MD=-2.49,95%CI=-4.91~-0.06,P=0.04)的效果优于单纯使用化学药,差异有统计学意义,但在降低PANSS阳性症状评分方面与单纯使用化学药的差异无统计学意义(MD=-1.67,95%CI=-3.80~0.67,P=0.13)。乌灵胶囊联合奥氮平降低PANSS一般精神病理症状评分的效果优于单纯使用奥氮平(MD=-5.38,95%CI=-9.08~-1.67,P=0.004);联合应用乌灵胶囊降低PANSS一般精神病理症状评分(MD=-5.57,95%CI=-7.62~-3.51,P<0.00001)、匹兹堡睡眠质量指数评分(MD=-2.13,95%CI=-4.11~-0.16,P=0.03)的效果优于单纯使用化学药,差异均有统计学意义。联合应用乌灵胶囊与单纯使用化学药的不良反应发生率、降低不良反应量表评分的效果比较,差异均无统计学意义(P>0.05)。结论:乌灵胶囊辅助治疗能够改善精神分裂症患者的阳性症状、阴性症状及一般精神病理症状,同时能够患者的睡眠质量,且安全性较好,但尚需更多高质量、大样本且长期随访的研究进一步确认疗效。
OBJECTIVE:To systematically review the efficacy and safety of Wuling capsule in adjuvant treatment of schizophrenia.METHODS:CBM,CNKI,Wanfang Data,VIP,PubMed,Web of Science,the Cochrane Library,Embase,OVID,CINAHL,Scopus,and APA PsycInfo were retrieved to collect randomized controlled trials of Wuling capsule in adjuvant treatment of schizophrenia(the control group received conventional treatment,while the research group was treated with Wuling capsule on the basis of the control group)from the database establishment to Apr.2024.Meta-analysis was performed by using RevMan 5.4 software after literature screening,data extraction and quality assessment according to inclusion and exclusion criteria.RESULTS:A total of 8 articles were enrolled,including 836 cases.Meta-analysis revealed that,the combined use of Wuling capsule was better than chemical drugs alone in reducing the total score of Positive and Negative Syndrome Scale(PANSS)(MD=-8.33,95%CI=-15.75--0.90,P=0.03)and PANSS negative symptom score(MD=-2.49,95%CI=-4.91--0.06,P=0.04),the difference was statistically significant,but there was no significant difference in the reduction of PANSS positive symptom scores compared with chemical drugs alone(MD=-1.67,95%CI=-3.80-0.67,P=0.13).The Wuling capsules combined with olanzapine was more effective in reducing the general psychopathological symptom score of PANSS than olanzapine alone(MD=-5.38,95%CI=-9.08--1.67,P=0.004);the effect of combined use of Wuling capsule in the reduction of PANSS general psychopathological symptom score(MD=-5.57,95%CI=-7.62--3.51,P<0.00001)and Pittsburgh sleep quality index(MD=-2.13,95%CI=-4.11--0.16,P=0.03)was better than that of chemical drugs alone,the differences were statistically significant.There was no statistically significant difference in the incidence of adverse drug reactions and reduction of adverse drug reaction scale scores between the combined use of Wuling capsule and chemical drugs alone(P>0.05).CONCLUSIONS:Wuling capsule can improve the positive symptoms,negative symptoms and general psychopathological symptoms of patients with schizophrenia,and improve the sleep quality of patients with good safety,which still needs more high-quality large samples and long-term follow-up study to further confirm the efficacy.
作者
侯靖萱
安春平
HOU Jin gxuan;AN Chunping(School of Humanities and Management,Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中国医院用药评价与分析》
2025年第10期1228-1231,1237,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
