摘要
甲状腺癌(TC)是内分泌系统最常见的恶性肿瘤。大部分患者早期经治疗后预后良好,但晚期TC仍缺乏有效治疗手段。甲状腺是人体免疫原性最强的组织之一,随着对TC免疫逃逸机制的深入研究以及免疫治疗在多种实体恶性肿瘤中的应用,TC的免疫检查点疗法表现出相当大的治疗潜力,为晚期TC患者带来了新的希望。该文重点综述了免疫检查点疗法在TC中的最新进展,以期为今后的研究提供新方向。
Thyroid cancer(TC)is the most prevalent malignancy of the endocrine system.While most patients achieve favorable prognoses with early treatment,patients with advanced TC face a scarcity of effective therapeutic strategies.The thyroid gland is one of the most immunogenic tissues in the human body.With the deepening understanding of immune evasion mechanisms in TC and the application of immunotherapy in various solid malignancies,immune checkpoint therapy for TC has shown considerable therapeutic potential,offering new hope for patients with advanced TC.This paper focuses on summarizing the latest advancements in immune checkpoint therapy for TC,aiming to provide new directions for future research.
作者
陈盼
姜允正
袁小洋
邹境辉
王乐彤
古凌威
Chen Pan;Jiang Yunzheng;Yuan Xiaoyang;Zou Jinghui;Wang Letong;Gu Lingwei(Department of Nuclear Medicine,Zhujiang Hospital of Southern Medical University,Guangzhou 510280,China;The First Clinical Medical College,Southern Medical University,Guangzhou 510515,China;The Second Clinical Medical College,Southern Medical University,Guangzhou 510280,China)
出处
《中华核医学与分子影像杂志》
北大核心
2025年第10期632-636,共5页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
南方医科大学珠江医院院长基金(yzjj2022qn32)
南方医科大学2023年度大学生创新创业训练计划项目(S202312121106)。
