摘要
目的 通过meta分析探讨无先兆偏头痛患者脑功能的特异性变化。方法 基于低频振幅(ALFF)、局部一致性(ReHo)、度中心度(DC)3种研究方法,检索PubMed、Web of Science、EMBASE、中国知网和万方数据库已收录的有关无先兆偏头痛患者静息态功能磁共振(rs-fMRI)相关病例对照研究,经文献筛选、质量评估及数据提取,采用激活似然估计法进行基于坐标的meta分析。结果 最终纳入22篇rs-fMRI相关研究。meta分析结果显示,与健康对照相比,无先兆偏头痛患者左侧楔叶、左侧顶上小叶、左侧后扣带回、左侧顶下小叶、右侧楔前叶、右侧角回等脑区的ALFF值降低,左侧梭状回、右侧梭状回、右侧颞中回、右侧海马旁回、右侧屏状核等脑区的DC值增高,而仅有右侧额中回的DC值降低。ReHo分析未提示显著差异。结论 无先兆偏头痛患者在静息状态下存在脑区特异性功能改变,可能是疾病发作的重要神经机制,有望成为干预治疗及疗效评估等的潜在影像学标志。
Objective The specific changes of brain function in patients with migraine without aura were explored through meta-analysis.Methods Based on amplitude of low-frequency fluctuation(ALFF),regional homogeneity(ReHo),and degree centrality(DC),case-control studies related to resting state functional magnetic resonance imaging(rs-fMRI)in patients with migraine without aura included in PubMed,Web of Science,EMBASE,China National Knowledge Infrastructure(CNKI),and Wanfang Database were retrieved.Through literature screening,quality assessment,and data extraction,coordinate meta-analysis was conducted using the activation likelihood estimation method.Results Eventually,22 rS-fMRI related studies were included.The results of the meta-analysis showed that compared with healthy controls,patients with migraine without aura had decreased ALFF values in brain regions such as the left cuneus,left parietal lobule,left posterior cingulate gyrus,left subparietal lobule,right precuneus,and right arcturus,while increased DC values in brain regions such as the left fusiform gyrus,right fusiform gyrus,right middle temporal gyrus,right parahippocampal gyrus,and right cuticular nucleus.However,only the DC value of the right midfrontal gyrus decreased.ReHo analysis did not suggest significant differences.Conclusion Patients with migraine without aura have specific functional changes in brain regions at rest,which may be an important neural mechanism for disease onset and is expected to become a potential imaging marker for intervention treatment and therapeutic effect evaluation.
作者
宋钰
宋亚涔
顾沈燕
SONG Yu;SONG Yacen;GU Shenyan(Department of Neurology,Nantong Tongzhou People's Hospital,Jiangsu Province,Nantong 226300,China;Department of Neurosurgery,Nantong Tongzhou People's Hospital,Jiangsu Province,Nantong 226300,China)
出处
《中国当代医药》
2025年第19期4-9,共6页
China Modern Medicine
关键词
无先兆偏头痛
功能磁共振成像
激活似然估计
低频振幅
局部一致性
度中心度
Migraine without aura
Functional magnetic resonance imaging
Activation likelihood estimation
Amplitude of low-frequency fluctuation
Regional homogeneity
Degree centrality
