摘要
胃癌是侵袭性和异质性较强的恶性肿瘤之一。基于精准分型指导下的胃癌个体化治疗是目前的研究热点。微卫星高度不稳定(microsatellite highly unstable,MSI-H)胃癌具有特定的临床特征、肿瘤微环境和病理学特征,这些已被作为评估胃癌患者预后的肿瘤标志物。近年来,免疫治疗给胃癌患者带来了新的治疗希望,其中MSI-H患者被认为是胃癌免疫治疗的优势人群。本文报道1例MSI-H转移性胃癌患者接受免疫治疗联合化疗,并结合文献复习,为临床实践提供参考。
Gastric cancer is one of the malignant tumors with strong invasion and heterogeneity.Individualized treatment of gastric cancer based on precise classification guidance is currently a research hotspot.Microsatellite instability-high(MSI-H)gastric cancer has specific clinical features,tumor microenvironment,and pathological characteristics,which have been used as tumor markers to evaluate the prognosis of gastric cancer patients.In recent years,immunotherapy has brought new hope for the treatment of gastric cancer patients,among whom MSI-H patients are considered the advantageous population for immunotherapy.This paper reports a case of MSI-H metastatic gastric cancer receiving immunotherapy combined with chemotherapy,and provides reference for clinical practice based on literature review.
作者
徐志宏
张倩
金辉
XU Zhihong;ZHANG Qian;JIN Hui(Department of Oncology,Fourth Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei Province,China)
出处
《肿瘤》
2025年第2期137-141,共5页
Tumor
关键词
胃癌
微卫星高度不稳定
免疫治疗
化疗
肿瘤微环境
Gastric cancer
Microsatellite instability-high
Immunotherapy
Chemotherapy
Tumor microenvironment
