摘要
目的:探究血清C肽(C-P)、胱抑素C(CysC)、总胆固醇(TC)水平联合检测对糖尿病肾病(DN)。方法:选取2022年9月-2024年1月于本院诊疗的89例DN患者为观察组,另选取同期89例单纯糖尿病患者为对照组。比较两组一般资料,分析促使DN发生的影响因素及联合诊断效能。结果:两组病程、收缩压及血清C-P、CysC、TC、空腹血糖水平比较,差异具有统计学意义(P<0.05);低水平C-P、高水平CysC、TC为促使DN发生的危险因素(P<0.05);血清C-P、CysC、TC水平联合诊断的AUC为0.836,最佳敏感度、特异度为87.64%、79.78%(P<0.05)。结论:血清C-P、CysC、TC水平与DN密切相关,可作为临床诊断疾病的参考指标。
Objective:To explore the diagnostic value of serum C-peptide(C-P),cystatin C(CysC)and total cholesterol(TC)in diabetic nephropathy(DN).Methods:Eighty-nine patients with DN treated in our hospital from September 2022 to January 2024 were selected as the observation group,and 89 patients only with diabetes were selected as the control group during the same period.General information of the two groups were compared to analyze the factors that promote the occurrence of DN and the efficiency of combined diagnosis.Results:The disease duration,systolic blood pressure and serum C-P,CysC,TC and fasting blood glucose levels were significantly diferent between the two groups(P<0.05).Low level of C-P,high level of CysC and TC were the risk factors for the occurrence of DN(P<0.05):The AUC of the combined diagnosis using serum C-P,CysC and TC levels was 0.836,with the best sensitivity and specificity being 87.64%and 79.78%,respectively(P<0.05):Conclusion:Serum C-P,CysC and TC levels are closely related to DN,which can be used as a reference index for clinical diagnosis.
作者
葛晓卫
梁琪雪
刘鑫
GE Xiao-wei;LIANG Qi-xue;LIU Xin(Molecular Biology Laboratory of Shangqiu Municipal Hospital,Henan Shangqiu 476000)
出处
《医学检验与临床》
2025年第9期21-24,52,共5页
Medical Laboratory Science and Clinics
关键词
C肽
胱抑素C
总胆固醇
糖尿病肾病
诊断
C-peptide
Cystatin C
Total cholesterol
Diabetic nephropathy
Diagnosis
