摘要
目的 比较阿奇霉素不同用药方式治疗小儿支气管肺炎的效果。方法 选取2022年1月-2024年1月于东乡区人民医院接受治疗的小儿支气管肺炎患儿68例为研究对象,根据随机数字表法将其分为对照组与研究组,各34例。两组均常规接受补充葡萄糖、降温等常规对症处理。对照组在常规处理的基础上接受阿奇霉素常规治疗,研究组在常规处理的基础上接受阿奇霉素序贯疗法。比较两组临床治疗效果、临床症状(发热、咳嗽、喘息、咳痰、肺啰音)改善用时、炎症因子水平[白细胞介素-8(IL-8)、干扰素-γ(INF-γ)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]、不良反应(肝功能异常、腹痛腹泻、皮疹)发生率。结果 研究组临床治疗总有效率高于对照组(P<0.05)。研究组发热、咳嗽、喘息、咳痰以及肺啰音消退用时均短于对照组(P<0.05)。治疗后,研究组炎症因子水平均低于对照组(P<0.05)。研究组不良反应发生率低于对照组(P<0.05)。结论 阿奇霉素序贯疗法治疗小儿支气管肺炎的效果确切,能够快速改善患儿临床症状,减轻患儿炎症反应,且安全性较高。
Objective To compare the effects of different medication methods of azithromycin in the treatment of bronchopneumonia in children.Methods A total of 68 children with bronchopneumonia who were treated in Dongxiang District People′s Hospital from January 2022 to January 2024 were selected as the research objects.According to the random number table method,they were divided into control group and study group,with 34 children in each group.Both groups received routine symptomatic treatment such as glucose supplementation and cooling.The control group received azithromycin routine treatment on the basis of routine treatment,and the study group received azithromycin sequential therapy on the basis of routine treatment.The clinical treatment effect,the improvement time of clinical symptoms(fever,cough,wheezing,expectoration,pulmonary rales),the levels of inflammatory factors[interleukin-8(IL-8),interferon-γ(INF-γ),C-reactive protein(CRP),interleukin-6(IL-6)],and the incidence of adverse reactions(abnormal liver function,abdominal pain,diarrhea,rash)were compared between the two groups.Results The total effective rate of clinical treatment in the study group was higher than that in the control group(P<0.05).The disappearance time of fever,cough,wheezing,expectoration and pulmonary rales in the study group was shorter than that in the control group(P<0.05).After treatment,the levels of inflammatory factors in the study group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the study group was lower than that in the control group(P<0.05).Conclusion Azithromycin sequential therapy is effective in the treatment of bronchopneumonia in children,which can quickly improve the clinical symptoms of children,reduce their inflammatory response,and has high safety.
作者
谢志霞
马珊萍
XIE Zhixia;MA Shanping(Department of Pharmacy,Dongxiang District People′s Hospital,Fuzhou 331800,Jiangxi,China)
出处
《医学信息》
2025年第20期123-126,共4页
Journal of Medical Information
关键词
阿奇霉素
用药方式
序贯治疗
支气管肺炎
Azithromycin
Medication methods
Sequential treatment
Bronchopneumonia
