摘要
主动脉瘤是一种血管退行性病变,其发病机制复杂。整合素作为一种细胞外基质受体,通过与细胞外基质成分结合,触发细胞内信号传导,调节血管平滑肌细胞功能,从而在维持主动脉正常结构和功能中发挥关键作用。本文对整合素与主动脉瘤发病相关的研究结果作一综述,为未来进一步深入探究其具体机制、开发新的治疗手段提供一定参考。
Aortic aneurysm is a degenerative vascular disorder characterized by complex pathogenesis.Integrin,functioning as critical extracellular matrix(ECM)receptors,mediate cell-ECM interactions by binding to ECM components,thereby triggering intracellular signaling cascades and modulating vascular smooth muscle cell functions.These processes are essential for maintaining aortic structural integrity and homeostasis.This review summarizes current research on the role of integrins in aortic aneurysm pathogenesis,providing a theoretical foundation for further mechanistic exploration and the development of novel therapeutic strategies.
作者
阿里亚·艾孜提艾力
阿斯亚·阿不得斯木
高文丽
马翔
Aliya·Aizitiaili;Asiya·Abudesimu;Gao Wenli;Ma Xiang(Heart Center,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
出处
《中国心血管杂志》
北大核心
2025年第5期631-634,共4页
Chinese Journal of Cardiovascular Medicine
基金
国家自然科学基金(82360090)。
