摘要
目的:分析总胆固醇(TC)/高密度脂蛋白胆固醇(HDL-C)比值、糖化血红蛋白(HbA1c)水平与糖尿病视网膜病变(DR)患者病情严重程度的相关性。方法:选取2022年10月至2024年3月该院收治的240例2型糖尿病患者进行前瞻性研究,依据散瞳眼底检查结果将其分为单纯2型糖尿病组(n=126)和DR组(n=114)。比较两组、不同病情严重程度DR患者TC/HDL-C比值、HbA1c水平,采用Spearman相关性分析TC/HDL-C比值、HbA1c水平与DR患者病情严重程度的相关性。结果:DR组TC/HDL-C比值、HbA1c水平均高于单纯2型糖尿病组,差异有统计学意义(P<0.05);中度、重度DR患者TC/HDL-C比值、HbA1c水平均高于轻度患者,且重度患者高于中度患者,差异有统计学意义(P<0.05);Spearman相关性分析结果显示,TC/HDL-C比值、HbA1c水平与DR患者病情严重程度均呈正相关(r>0,P<0.05)。结论:TC/HDL-C比值、HbA1c水平与DR患者病情严重程度均呈正相关。
Objective:To analyze correlation between total cholesterol(TC)/high-density lipoprotein cholesterol(HDL-C)ratio and glycosylated hemoglobin(HbA1c)level and severity diabetic retinopathy(DR).Methods:A prospective study was conducted on 240 patients with type 2 diabetes admitted to the hospital from October 2022 to March 2024.According to the results of mydriatic fundus examination,they were divided into simple type 2 diabetes group(n=126)and DR group(n=114).The TC/HDL-C ratio and the HbA1c level were compared between the two groups and among the DR patients with different severity.Spearman correlation analysis was used to analyze the correlation between TC/HDL-C ratio and HbA1c level and the severity of the DR patients.Results:The TC/HDL-C ratio and the HbA1c level in the DR group were higher than those in the simple type 2 diabetes group,and the differences were statistically significant(P<0.05).The levels of TC/HDL-C ratio and HbA1c in the moderate and severe DR patients were higher than those in the mild DR patients,those in the severe DR patients were higher than those in the moderate DR patients,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that the TC/HDL-C ratio and HbA1c level were positively correlated with the severity of the DR patients(r>0,P<0.05).Conclusions:The TC/HDL-C ratio and HbA1c level are positively correlated with the severity of the DR patients.
作者
陆蕾芳
管佳丽
LU Leifang;GUAN Jiali(Department of Clinical Laboratory of Jiangyin Surgery Hospital of Traditional Chinese Medicine,Jiangyin 214400 Jiangsu,China)
出处
《中国民康医学》
2025年第20期136-138,共3页
Medical Journal of Chinese People’s Health
