摘要
目的:分析颈动脉超声参数、血清NOD样受体蛋白3(NLRP3)水平与糖尿病合并动脉粥样硬化性心血管疾病(ASCVD)的相关性。方法:回顾性分析2022-2023年该院收治的194例糖尿病患者的临床资料,根据是否合并ASCVD将其分为合并ASCVD组(66例)与未合并ASCVD组(128例)。另回顾性分析同期该院97名健康体检者的临床资料,设为对照组。三组均进行颈动脉超声检查、血清NLRP3水平检测和ASCVD判定,比较三组颈动脉超声参数[颈动脉内膜中层厚度(IMT)、阻力指数(RI)、搏动指数(PI)、收缩期峰值流速(PSV)、舒张末期流速(EDV)]、血清NLRP3水平,采用Spearman相关性分析颈动脉超声参数、血清NLRP3水平与糖尿病合并ASCVD的相关性。结果:未合并ASCVD组、合并ASCVD组IMT、RI、PI和血清NLRP3水平均高于对照组,且合并ASCVD组均高于未合并ASCVD组,未合并ASCVD组、合并ASCVD组PSV、EDV水平均低于对照组,且合并ASCVD组低于未合并ASCVD组,差异有统计学意义(P<0.05);Spearman相关性分析结果显示,IMT、RI、PI和血清NLRP3水平与糖尿病合并ASCVD均呈正相关(r>0,P<0.05),PSV、EDV水平与糖尿病合并ASCVD均呈负相关(r<0,P<0.05)。结论:IMT、RI、PI和血清NLRP3水平与糖尿病合并ASCVD均呈正相关,PSV、EDV水平与糖尿病合并ASCVD均呈负相关。
Objective:To analyze correlation between levels of carotid ultrasound parameters and serum NOD-like receptor protein 3(NLRP3)and diabetes mellitus complicated with atherosclerotic cardiovascular disease(ASCVD).Methods:The clinical data of 194 diabetic patients admitted to this hospital from 2022 to 2023 were retrospectively analyzed.They were divided into ASCVD group(66 cases)and non-ASCVD group(128 cases)according to whether ASCVD was combined.The clinical data of 97 healthy subjects in the hospital during the same period were retrospectively analyzed and they were set as the control group.The carotid ultrasound examination,the serum NLRP3 level detection and the ASCVD determination were performed in all three groups.The levels of carotid ultrasound parameters[carotid intima-media thickness(IMT),resistance index(RI),pulsatility index(PI),peak systolic velocity(PSV),end-diastolic velocity(EDV)]and serum NLRP3 were compared among the three groups.Spearman correlation was used to analyze the correlation between the levels of carotid ultrasound parameters and serum NLRP3 and diabetes mellitus complicated with ASCVD.Results:The levels of IMT,RI,PI and serum NLRP3 in the non-ASCVD group and the ASCVD group were higher than those in the control group,and those in the ASCVD group were higher than those in the non-ASCVD group;the levels of PSV and EDV in the non-ASCVD group and the ASCVD group were lower than those in the control group,and those in the ASCVD group were lower than those in the non-ASCVD group;and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that the levels of IMT,RI,PI and serum NLRP3 were positively correlated with diabetes mellitus complicated with ASCVD(r>0,P<0.05),while the PSV and EDV levels were negatively correlated with diabetes mellitus complicated with ASCVD(r<0,P<0.05).Conclusions:The levels of IMT,RI,PI and serum NLRP3 are positively correlated with diabetes mellitus complicated with ASCVD,while the PSV and EDV levels are negatively correlated with diabetes mellitus complicated with ASCVD.
作者
祝豫辰
ZHU Yuchen(Department of Ultrasound of Runan County People’s Hospital,Zhumadian 463300 Henan,China)
出处
《中国民康医学》
2025年第20期125-127,共3页
Medical Journal of Chinese People’s Health
关键词
颈动脉超声参数
NOD样受体蛋白3
糖尿病
动脉粥样硬化性心血管疾病
相关性
Carotid artery ultrasound parameter
NOD-like receptor protein 3
Diabetes mellitus
Atherosclerotic cardiovascular disease
Correlation
