摘要
目的:观察自拟香砂温胆汤加减联合常规西药治疗糜烂性胃炎(EG)患者的效果。方法:回顾性分析2023年1月至2024年2月该院收治的80例EG患者的临床资料,根据治疗方法不同将其分为对照组和观察组各40例。对照组采用常规西药治疗,观察组在对照组基础上联合自拟香砂温胆汤加减治疗。比较两组临床疗效,治疗前后中医证候积分、胃黏膜病变程度[改良Lanza评分(MLS)]评分、胃功能指标[胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、胃泌素-17(G-17)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.00%(38/40),高于对照组的80.00%(32/40),差异有统计学意义(P<0.05);治疗后,两组中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组MLS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组PGⅠ、PGⅡ、G-17水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:自拟香砂温胆汤加减联合常规西药治疗EG患者可提高治疗总有效率和胃功能指标水平,降低中医证候积分和胃黏膜病变程度评分,效果优于单纯常规西药治疗。
Objective:To observe effects of self-made Xiangsha Wendan decoction combined with conventional Western medicine in treatment of patients with erosive gastritis(EG).Methods:The clinical data of 80 patients with EG admitted to this hospital from January 2023 to February 2024 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,40 cases in each group.The control group was treated with conventional Western medicine,while the observation group was treated with self-made Xiangsha Wendan decoction on the basis of that of the control group.The clinical efficacy,the TCM syndrome score,the gastric mucosal lesion degree[modified Lanza score(MLS)]score,the gastric function indexes[pepsinogen I(PGI),pepsinogen II(PGII),gastrin-17(G-17)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.00%(38/40),which was higher than 80.00%(32/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the MLS scores of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PGI,PGII and G-17 in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Self-made Xiangsha Wendan decoction combined with conventional Western medicine in the treatment of the EG patients can improve the total effective rate of treatment and the levels of gastric function indexes,reduce the TCM syndrome scores and the degree of gastric mucosal lesion scores.Moreover,it is superior to simple conventional Western medicine treatment.
作者
刘雪艳
LIU Xueyan(Department of Gastroenterology of Shangqiu Hospital of Traditional Chinese Medicine,Shangqiu 476000 Henan,China)
出处
《中国民康医学》
2025年第20期104-107,共4页
Medical Journal of Chinese People’s Health
关键词
糜烂性胃炎
香砂温胆汤
中医证候积分
胃功能
胃黏膜病变程度
不良反应
Erosive gastritis
Xiangsha Wendan decoction
TCM syndrome score
Gastric function
Gastric mucosal lesion degree
Adverse reaction
