摘要
目的:观察腹腔镜手术联合腹主动脉旁淋巴结清扫术(PAND)治疗子宫内膜癌(EC)患者的效果。方法:选取2022-2024年该院收治的70例EC患者进行前瞻性研究,按照随机数字表法将其分为观察组和对照组各35例。观察组行腹腔镜手术联合PAND治疗,对照组行开腹手术联合PAND治疗。比较两组围手术期指标(手术时间、术中出血量、住院时间)水平,术后不同时间疼痛[视觉模拟评分法(VAS)]评分,手术前后肿瘤标志物[人表皮生长因子受体2(HER2)、糖类抗原125(CA125)、癌胚抗原(CEA)]水平,以及并发症发生率。结果:观察组手术时间长于对照组,术中出血量少于对照组,住院时间短于对照组,差异均有统计学意义(P<0.05);术后1、3 d,观察组VAS评分均低于对照组,差异有统计学意义(P<0.05);术后,两组HER2、CA125、CEA水平均低于术前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:腹腔镜手术联合PAND治疗EC患者可减少术中出血量,缩短住院时间,降低疼痛评分、肿瘤标志物水平和并发症发生率,效果优于开腹手术联合PAND治疗,但会延长手术时间。
Objective:To observe effects of laparoscopic surgery combined with para-aortic lymph node dissection(PAND)in treatment of patients with endometrial carcinoma(EC).Methods:A prospective study was conducted on 70 patients with EC admitted to the hospital from 2022 to 2024.According to the random number table method,they were divided into observation group and control group,35 cases in each group.The observation group was treated with laparoscopic surgery combined with PAND,while the control group was treated with open surgery combined with PAND.The levels of perioperative indicators(operation time,intraoperative blood loss,hospitalization time),the pain[visual analogue scale(VAS)]scores at different time after the surgery,the tumor markers[human epidermal growth factor receptor 2(HER2),carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA)]levels before and after the surgery,and the incidence of complications were compared between the two groups.Results:The operation time of the observation group was longer than that of the control group,the intraoperative blood loss was less than that of the control group,the hospitalization time was shorter than that of the control group,and the differences were statistically significant(P<0.05).1 and 3 days after the surgery,the VAS scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After the surgery,the levels of HER2,CA125 and CEA in the two groups were lower than those before the surgery,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusions:Laparoscopic surgery combined with PAND in the treatment of the EC patients can reduce the intraoperative blood loss,shorten the hospitalization time,and reduce the pain scores,the tumor marker levels and the incidence of complications.It is superior to open surgery combined with PAND treatment,but it will prolong the operation time.
作者
马芳芳
MA Fangfang(Department of Gynecology of Xihua County People’s Hospital,Zhoukou 466000 Henan,China)
出处
《中国民康医学》
2025年第20期60-62,共3页
Medical Journal of Chinese People’s Health
