摘要
目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)结合草酸艾司西酞普兰治疗老年抑郁伴认知障碍的临床效果。方法目的选取2022年1月—2024年9月南通市第二人民医院收治的80例老年抑郁伴认知障碍患者为研究对象。根据治疗方案不同分为两组,对照组(40例)给予草酸艾司西酞普兰治疗;观察组(40例)在对照组基础上结合rTMS治疗。对比两组抑郁改善情况、认知功能恢复情况及治疗效果。结果治疗前,两组患者汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)评分比较,差异无统计学意义(P>0.05);治疗后,两组HAMD评分均下降,且观察组HAMD评分低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评分比较,差异均无统计学意义(P均>0.05);治疗后,两组MoCA评分均升高,且观察组MoCA评分高于对照组,差异均有统计学意义(P均<0.05)。对照组治疗有效率为65.00%(26/40),低于观察组的85.00%(34/40),差异有统计学意义(χ^(2)=4.267,P<0.05)。结论老年抑郁伴认知障碍,可在草酸艾司西酞普兰治疗基础上,结合rTMS治疗,能够更加有效改善患者抑郁情况,促进其认知功能恢复,可达到良好的疗效。
Objective To investigate the clinical effect of repetitive transcranial magnetic stimulation(rTMS)combined with escitalopram oxalate in the treatment of elderly depression with cognitive impairment.Methods A total of eighty elderly patients with depression and cognitive impairment admitted to Nantong Second People's Hospital from January 2022 to September 2024 were purposefully selected as the study subjects.According to different treatment regimens,they were divided into two groups.The control group(forty cases)was treated with escitalopram oxalate.The observation group(forty cases)was treated with rTMS on the basis of the control group.The recovery of cognitive function and therapeutic effect of depression improvement were compared between the two groups.Results Before treatment,there was no significant difference in Hamilton Depression Scale(HAMD)score between the two groups(P>0.05).After treatment,the HAMD scores of the two groups decreased,and the HAMD score of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in Montreal Cognitive Assessment(MoCA)scores between the two groups(all P>0.05).After treatment,the MoCA scores of the two groups increased,and the MoCA score of the observation group were higher than that of the control group,the differences were statistically significant(all P<0.05).The effective rate of treatment in the control group was 65.00%(26/40),which was lower than 85.00%(34/40)in the observation group,and the difference was statistically significant(χ^(2)=4.267,P<0.05).Conclusion Elderly depression with cognitive im‐pairment,on the basis of escitalopram oxalate treatment,combined with rTMS treatment,can more effectively improve the depression of patients,promote the recovery of cognitive function,and achieve good results.
作者
秦小杰
夏静
徐萍
吴新贺
QIN Xiaojie;XIA Jing;XU Ping;WU Xinhe(Department of Geriatrics,Nantong Second People's Hospital,Nantong 226000,Jiangsu,China;Department of Neu‐rological Rehabilitation,Nantong Second People's Hospital,Nantong 226000,Jiangsu,China)
出处
《系统医学》
2025年第17期115-118,共4页
Systems Medicine
基金
2024年度南通市市级科技计划指导性项目(MSZ2024088)。
关键词
重复经颅磁刺激
草酸艾司西酞普兰
抑郁症
认知障碍
临床效果
Repetitive transcranial magnetic stimulation
Escitalopram oxalate
Depression
Cognitive impairment
Clinical efficacy
