摘要
泌尿系统肿瘤作为严重威胁人类健康的重大疾病之一,其精准诊疗体系的构建亟待突破。基于分子影像技术的创新应用,特别是新型分子探针的研发,正在重塑泌尿肿瘤的诊疗范式。本文系统综述新型分子探针在泌尿肿瘤早期诊断与分期中的应用、多模态分子影像探针引导精准手术/放疗及诊疗一体化探针临床转化挑战与策略,旨在为相关研究和临床应用提供参考。
Genitourinary system tumors,as a major clinical challenge posing a serious threat to human health,urgently require breakthroughs in the construction of a precision diagnosis and treatment system.The innovative application of molecular imaging technologies,particularly the development of novel molecular probes,is revolutionizing the diagnostic and therapeutic paradigms for urinary tumors.The application of novel molecular probes in the early diagnosis and staging of genitourinary tumors,the role of multimodal molecular imaging probes in guiding precision surgery/radiotherapy,and the clinical translation challenges and strategies for theranostic-integrated probes are systematically reviewed in this article to provide valuable insights and references for related research and clinical practice.
作者
孙明伟
郭鹏宇
徐万海
SUN Mingwei;GUO Pengyu;XU Wanhai(Department of Urology,Harbin Medical University Cancer Hospital,Harbin 150081,China;NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics,Harbin 150001,China;Department of Urology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《肿瘤防治研究》
2025年第10期811-817,共7页
Cancer Research on Prevention and Treatment
基金
黑龙江省自然科学基金优秀青年项目(YQ2024H024)
海燕科研基金(JJZD2024-05)。
关键词
分子探针
泌尿系统肿瘤
精准诊疗
多模态成像
Molecular probe
Urinary system tumor
Precision diagnosis and treatment
Multimodal imaging
