摘要
强直性脊柱炎(ankylosing spondylitis,AS)是一种慢性炎症性疾病,主要累及中轴关节,严重者可发生脊柱畸形和关节强直,导致残疾。病理性新骨形成是导致AS患者关节强直、脊柱畸形的病理基础。成骨通路与AS病理性新骨形成密切相关。中药具有多成分、多靶点、多通路的作用特点,临床治疗AS疗效确切。该文通过分析、归纳与AS病理性新骨形成相关的成骨通路(Wnt/β-catenin、BMP/Smad信号通路)及中医药抑制成骨通路治疗AS病理性新骨形成的研究进展,可为中医药治疗AS提供科学依据。
Ankylosing spondylitis(AS)is a chronic inflammatory disease primarily affecting the axial joints,with severe cases leading to spinal deformities and joint ankylosis,resulting in disability.Pathological new bone formation is the pathological basis for joint ankylosis and spinal deformities in AS patients.Osteogenic pathways are closely associated with pathological new bone formation in AS.Traditional Chinese medicine(TCM)exhibits multi-component,multi-target,and multi-pathway therapeutic characteristics,demonstrating clinically validated efficacy in AS treatment.This review analyzes and summarizes the osteogenic pathways(Wnt/β-catenin and BMP/Smad signaling pathways)involved in pathological new bone formation in AS,as well as the research progress on TCM interventions targeting these pathways to inhibit pathological new bone formation.The aim is to provide scientific evidence for TCMbased treatment of AS.
作者
苏瑾
杨娟娟
李浩林
王振东
芦栋生
陈平
王海东
SU Jin;YANG Juanjuan;LI Haolin;WANG Zhendong;LU Dongsheng;CHEN Ping;WANG Haidong(Gansu University of Traditional Chinese Medicine,Lanzhou 730000 Gansu,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050 Gansu,China)
出处
《中药新药与临床药理》
北大核心
2025年第10期1808-1818,共11页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
甘肃省科技计划项目(23JRRA1535)。
