摘要
本文从现代医学及中医学角度对冠状动脉介入治疗术后再狭窄(ISR)的临床和(或)基础研究相关文献进行整理归纳,浅述ISR的中西医病理机制。现代医学对冠心病ISR机制的认识集中在新生动脉粥样硬化(ISNA)、新生内膜增殖(NIH)、炎症反应等方面,三个环节互相影响,共同促进了支架后再狭窄的发生;中药单体复方在防治ISR方面的病理机制多集中在减轻控制PCI术后炎症反应、促血管内皮化发生等方面。通过以上总结以期对ISR防治提供新的思路和研究方向。
In this paper,from the perspective of modern medicine and traditional Chinese medicine,related literatures on the clinical and/or basic research of postoperative restenosis(ISR)after coronary intervention were summarized,and the pathological mechanism of ISR was briefly described.Modern medical understanding of the mechanism of ISR in coronary heart disease focuses on neonatal atherosclerosis(ISNA),neonatal intimal proliferation(NIH),inflammation,etc.The three links interact with each other and jointly promote the occurrence of post-stent restenosis.The pathological mechanism of TCM monomer compound in the prevention and treatment of ISR mainly focuses on reducing and controlling the inflammation after PCI and promoting the occurrence of vascular endothelialization.The above conclusions are expected to provide new ideas and research directions for the prevention and treatment of ISR.
作者
陈婷
马振
胡元会
柴若宁
杨雄星
刘挺
CHEN Ting;MA Zhen;HU Yuan-hui;CHAI Ruo-ning;YANG Xiong-xing;LIU Ting(Department of Cardiology,Xi’an Hospital of Traditional Chinese Medicine,Xi’an 710021,Shaanxi,China;Department of Cardiology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)
出处
《心脏杂志》
2025年第5期601-605,共5页
Chinese Heart Journal
基金
国家中医药管理局中医药古籍文献和特色技术传承专项(GZY-KJS-2020-025)。
关键词
冠心病
介入治疗
再狭窄
病理机制
中西医
coronary heart disease
interventional therapy
restenosis
pathological mechanism
Chinese and Western medicine
