摘要
高迁移率族蛋白B1(HMGB1)是HMGs家族中存在最为广泛的蛋白成员,因参与机体的炎症反应而被熟知,研究发现其在细胞的迁移、免疫识别、神经保护等方面都起着关键作用。脊髓损伤是一种对神经系统具有严重破坏性的疾病,脊髓损伤后神经环路受到破坏,出现缺血缺氧、炎症反应、脱髓鞘病变、胶质瘢痕形成等诸多不利于神经再生和修复的情况,使其成为现代脊柱外科领域最为难治的疾患之一。HMGB1在脊髓损伤后表达升高,调控神经性炎症反应,还可参与神经细胞凋亡、促进神经元再生、诱导神经干细胞分化和迁移,在神经功能恢复过程中起到重要作用。本文就HMGB1的结构和功能,及其在脊髓损伤中的作用研究进行总结,为寻找脊髓损伤神经功能恢复的治疗靶点提供方向。
High mobility group box protein 1(HMGB1)is one of the most widely expressed protein member in the HMGs family,which is well known for its involvement in the body inflammatory response.Previous researches have found that it plays a significant role in cell migration,immune identification and neuroprotection.Spinal cord injury is a disease that causes severe damage to the nervous system,and neural circuits are disrupted after a spinal cord injury,which leads to many conditions including ischemia and hypoxia,inflammatory responses,demyelinating lesions,and glial scar formation that are detrimental to nerve regeneration and repair,making it one of the most difficult diseases to treat in the modern spinal surgery field.HMGB1 is upregulated after spinal cord injury,thereby regulating neuroinflam⁃matory responses,and participating in the neuronal apoptosis,promoting neuronal regeneration,and inducing neural stem cell differentiation and migration,which plays an important role in the process of neural function recovery.This paper summarizes the structure and function of HMGB1,as well as its role in spinal cord injury,in order to provide direction for founding therapeutic target for neurological function recovery after spinal cord injury.
作者
薛鑫
殷长征
陈金辉
黄禄荣
郑欣
李奕敏
肖国保
张萍
赵建华
XUE Xin;YIN Chang-zheng;CHEN Jin-hui;HUANG Lu-rong;ZHENG Xin;LI Yi-min;XIAO Guo-bao;ZHANG Ping;ZHAO Jian-hua(Ward 5 of Second Surgery Department(Department of Spinal Surgery),the PLA No.96603 Army Hospital,Huaihua Hunan 418000,China;Department of Spinal Surgery,Army Medical Center,Chongqing 400042,China)
出处
《局解手术学杂志》
2025年第10期918-923,共6页
Journal of Regional Anatomy and Operative Surgery
基金
国家自然科学面上项目(81972068)。
