摘要
以磺酰亚胺和β-酮酸为原料,利用有机膦酸催化,设计合成了6个新型联苯七元环磺酰胺类化合物并进行了抑菌活性初探,其结构通过1H NMR、^(13)C NMR和高分辨质谱等技术进行确定。结果显示,化合物3c和3e对大肠杆菌、表皮葡萄球菌和耐甲氧西林金黄色葡萄球菌具有一定抑菌效果。该合成方法条件温和,操作简便,为抑菌药物研发提供候选分子。
Using sulfonyl imides andβ-keto acids as starting materials,six novel biphenyl-fused seven-membered sulfonamide compounds were designed and synthesized via organophosphonic acid catalysis,and their antibacterial activities were preliminarily investigated.Their structures were confirmed by 1H NMR,^(13)C NMR,and high-resolution mass spectrometry(HRMS).The results showed that compounds 3c and 3e exhibited certain antibacterial effects against Escherichia coli,Staphylococcus epidermidis,and methicillin-resistant Staphylococcus aureus(MRSA).This synthetic method features mild conditions and simple operation,providing candidate molecules for the development of antibacterial drugs.
作者
陈晴晴
努尔阿米娜木·亚森
高振鲁
杨坤
骈继鑫
Chen Qingqing;Nur Aminamu Yasin;Gao Zhenlu;Yang Kun;Pian Jixin(Xinjiang Second Medical College,Karamay 834000,China)
出处
《当代化工研究》
2025年第17期188-190,共3页
Modern Chemical Research
基金
新疆维吾尔自治区研究生创新科研计划(XJ2025G021)
新疆维吾尔自治区高等学校科学研究计划(XJEDU2023P162)。
关键词
磺酰亚胺
β-酮酸
环状磺酰胺
抑菌活性
sulfonyl imine
β-keto acid
cyclic sulfonamide
antibacterial activity
