摘要
目的观察芍麻止痉颗粒治疗儿童抽动障碍的临床效果。方法选取2021年1月至2023年12月就诊于江南大学附属医院儿科的86例符合肝亢风动证或痰火扰神证的抽动障碍患儿,采用随机数字表法分为对照组、观察组,各43例。对照组予盐酸硫必利片治疗,观察组予芍麻止痉颗粒治疗,疗程为12周。根据耶鲁综合抽动严重程度量表(YGTSS)治疗前与治疗后的减分率作为判定疗效的依据,比较两组疗效、YGTSS评分、中医证候评分、炎症因子[肿瘤坏死因子-α(TNF-α)与白细胞介素-6(IL-6)]水平及不良反应。结果观察组和对照组治疗总有效率比较,差异无统计学意义(P>0.05)。两组治疗前、治疗后YGTSS评分比较无明显差别(P>0.05);在第12周末,两组YGTSS评分均降低(P<0.05)。治疗前两组中医证候比较差异不明显(P>0.05);治疗后与对照组相比,观察组中医证候评分更低(P<0.05)。治疗前两组TNF-α、IL-6水平比较无差异(P>0.05);治疗后两组TNF-α、IL-6水平均降低,观察组低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论芍麻止痉颗粒与盐酸硫必利片治疗儿童抽动障碍均有良好的疗效,芍麻止痉颗粒可以改善中医证候,降低TNF-α、IL-6水平。
Objective To observe the clinical effect of Shaoma Zhijing Granules in the treatment of children with tic disorder.Methods A total of 86 children with tic disorder who were treated in the Pediatrics Department of Affiliated Hospital of Jiangnan University from January 2021 to December 2023 and met the syndrome of hyperlipitis with wind movement or phlegm-fire disturbing the mind were selected and divided into a control group and an observation group by the random number table method,with 43 children in each group.The control group was treated with Tiapride Hydrochloride Tablets,and the observation group was treated with Shaoma Zhijing Granules,with a course of treatment of 12 weeks.The score reduction rate before and after treatment according to the Yale global tic severity scale(YGTSS)was used as the basis for judging the curative effect.The curative effect,YGTSS score,traditional Chinese medicine syndrome score,levels of inflammatory factors(tumor necrosis factor-α[TNF-α]and interleukin-6[IL-6])and adverse reactions were compared between the two groups.Results The comparison of the overall effective rate between the observation group and the control group showed no statistically significant difference(P>0.05).There were no significant differences in YGTSS scores before and after treatment between the two groups(P>0.05).On the twelfth weekend,both groups showed a decrease in YGTSS scores(P<0.05).Before treatment,the difference in traditional Chinese medicine syndrome score between the two groups was not significant(P>0.05).After treatment,the observation group exhibited lower traditional Chinese medicine syndrome score compared to the control group(P<0.05).There were no significant differences in TNF-αand IL-6 levels between the two groups before treatment(P>0.05).After treatment,both groups showed decreased levels of TNF-αand IL-6,with the observation group exhibiting lower levels than the control group(P<0.05).The overall incidence rate of adverse reactions between the two groups showed no statistically significant difference(P>0.05).Conclusion Both Shaoma Zhijing Granules and Tiapride Hydrochloride Tablets have good clinical effect in the treatment of children with tic disorder.Shaoma Zhijing Granules can improve the symptoms of traditional Chines e medicine,and reduce the levels of TNF-αand IL-6.
作者
王春红
刘月影
WANG Chunhong;LIU Yueying(Department of Pediatrics,Affiliated Hospital of Jiangnan University,Jiangsu Province,Wuxi 214122,China)
出处
《妇儿健康导刊》
2025年第19期193-198,共6页
Journal of Women and Children's Health Guide
基金
江苏省中医药学会科研项目(PDJH2024027)。
