摘要
目的 探究复发型多发骨髓瘤(RMM)患者二线化疗的疗效及其影响因素。方法 回顾性收集2021年2月至2024年5月于商丘市第一人民医院进行二线化疗的RMM患者56例,以国际骨髓瘤工作组(IMWG)制定的疗效判定标准将其分为有效组(n=37)和无效组(n=19)。汇总患者各项临床数据,并利用Logistic回归模型分析RMM患者二线化疗治疗效果的影响因子。结果 本研究共纳入56例RMM患者,二线化疗有效的患者有37例(66.07%),包括完全缓解6例(16.22%)、很好的部分缓解14例(37.84%)、部分缓解17例(45.95%)。两组患者在年龄、国际分期系统(ISS)分期、血红蛋白(Hb)、染色体、肾功能是否受损等方面不存在显著差异(P>0.05)。然而,有效组与无效组在性别、白细胞计数(WBC)、血小板计数(PLT)、碱性磷酸酶(ALP)与骨钙素(BGP)方面差异显著(P>0.05)。多因素分析示,PLT、ALP及BGP是影响RMM患者二线化疗疗效的独立危险因素。结论 二线化疗治疗RMM患者具有显著疗效,而PLT、ALP及BGP是影响RMM患者二线化疗疗效的关键因素。
Objective To investigate the efficacy of second-line chemotherapy in patients with recurrent multiple myeloma(RMM)and its influencing factors.Methods A total of 56 patients with RMM who underwent second-line chemotherapy in the First People's Hospital of Shangqiu from February 2021 to May 2024 were enrolled in the study.They were divided into the effective group(n=37)and the ineffective group(n=19)according to the efficacy evaluation criteria set by the International Myeloma Working Group(IMWG).The patients’clinical data were collected,and multi-factor logistic regression model was used to analyze factors influencing the efficacy of second-line chemotherapy in patients with RMM.ResultsIn this study,there were 37(66.07%)patients with response to second-line chemotherapy,including 6(16.22%)cases of complete remission,14(37.84%)cases of good partial remission,and 17(45.95%)cases of partial remission.There were no significant differences between the effective group and the ineffective group in terms of age,International Staging System(ISS)staging,hemoglobin(Hb),chromosomes,and renal function(P>0.05).However,there were significant differences between the effective group and the ineffective group in terms of gender,white blood cell count(WBC),platelet count(PLT),alkaline phosphatase(ALP),and bone gla protein(BGP)(P<0.05).Multi-factor logistic regression analysis found that PLT,ALP,and BGP were independent risk factors influencing the efficacy of second-line chemotherapy in patients with RMM.Conclusion Second-line chemotherapy is marked effective for patients with RMM.PLT,ALP,and BGP are key factors influencing the efficacy of second-line chemotherapy in patients with RMM.
作者
申晗
王根杰
杨硕
SHEN Han;WANG Gen-jie;YANG Shuo(Department of Hematology,The First People's Hospital of Shangqiu,Shangqiu 476000,Henan Province,China)
出处
《罕少疾病杂志》
2025年第10期126-127,142,共3页
Journal of Rare and Uncommon Diseases
关键词
复发型多发骨髓瘤
二线化疗
疗效
影响因素
Recurrent Multiple Myeloma
Second-line Chemotherapy
Efficacy
Influencing Factor
