摘要
目的 探讨肾周脂肪面积(PFA)与肾细胞癌(RCC)患者预后及病理分级的相关性。方法 回顾性分析2018年1月至2025年1月期间山西白求恩医院收治的150例RCC患者的临床及影像学资料,对其追踪随访,根据随访结果将其分为预后良好组及进展复发组,记录其中126例透明细胞肾细胞癌(cc RCC)的病理分级,根据结果分为高级别组及低级别组,应用3D Slicer软件计算肾周脂肪面积(PFA)、腹壁皮下脂肪面积(SFA)、内脏脂肪面积(VFA),并计算肾周脂肪聚集程度(PFA%)。分析2组临床资料及上述测量指标之间的差异,并应用logistic回归分析判断各因素在病理分级中的相关性。结果 预后良好组的PFA与PFA%均小于进展复发组(P=0.018、P=0.003),而SFA及VFA 2组间差异无统计学意义(P>0.05)。在透明细胞肾细胞癌(ccRCC)病理分级模型中,高级别组患者PFA%更高(P=0.019),肿瘤最大径更大(P=0.006),而PFA、SFA、VFA差异无统计学意义(P>0.05)。PFA%与透明细胞RCC的病理分级密切相关[OR值(95%CI)=1.113(1.008,1.230),P=0.034]。结论 肾周脂肪范围是预测RCC患者恶性程度和预后的潜在指标。
Objective To investigate the correlation between perirenal fat area(PFA)and the prognosis and pathological grade of patients with renal cell carcinoma(RCC).Methods The clinical and imaging data of 150 patients with RCC admitted to Shanxi Bethune Hospital from January 2018 to January 2025 were retrospectively analyzed,and they were divided into good prognosis group and advanced recurrence group according to the follow-up results,and the pathological grade of 126 cases of clear cell renal cell carcinoma(ccRCC)was recorded.The visceral fat area(VFA)was calculated,and the degree of perirenal fat aggregation(PFA%),PFA%=PFA/(SFA+VFA)×100%.The differences between the clinical data and the above measurement indicators were analyzed,and the correlation of each factor in the pathological grade was determined by logistic regression analysis.Results The PFA and PFA%of the prognosis group were lower than those of the advanced recurrence group(P=0.018,P=0.003),but there was no significant difference between the SFA and VFA groups(P>0.05).In the pathological grading model of ccRCC,the PFA%of patients in the high-grade group was higher(P=0.019)and the maximum diameter of tumors was larger(P=0.006).There was no significant difference in PFA,SFA and VFA between the two(P>0.05),and PFA%was closely related to the pathological grade of clear cell renal cell carcinoma[OR(95%CI)=1.113(1.008,1.230),P=0.034].Conclusion Perirenal fat range is a potential index for predicting the degree of malignancy and prognosis of RCC patients.
作者
尉晓珊
吴山
Yu Xiaoshan;Wu Shan(Department of Radiology,Shangxi Bethune Hospital,Shanxi Academy of Medical Science,Third Hospital of Shanxi Medical University,Tongji Shanxi Hospital,Taiyuan 030032,China)
出处
《实用医技杂志》
2025年第9期682-685,I0003,共5页
Journal of Practical Medical Techniques
关键词
癌
肾细胞
肾周脂肪
肥胖
Carcinoma,renal cell
Perirenal fat
Obesity
