摘要
Physiological and pathological processes such as embryonic development and tumor progression involve complicated interplay of mechanical,chemical,and biological factors cross a wealth of spatial and temporal scales.In this paper,we review some recent advances in the field of mechano-chemo-biological coupling theories in biological tissues and cells,and their applications in cancer,immunological,and other diseases.Key issues in the mechano-chemo-biological modeling of specific dynamic processes of cells and tissues are discussed.A mechano-chemo-biological growth theory is introduced,which interrogates the mechanical,chemical,and biological coupling mechanisms underpinning the growth,remodeling and degradation of tissues such as tumors.The mechano-chemo-biological instabilities of cells and tissues are systematically analyzed,with particular attention to those induced by coupled mechano-chemo-biological mechanisms.Furthermore,we provide a mechano-chemo-biological multiscale computational framework to investigate the dynamic processes of cells and tissues,for example,the migration and metastasis of cancer cells.Besides,we discuss some recent theoretical and experimental findings in the mechano-chemo-biological dynamics of collective cells.Finally,perspectives and clinical applications of the mechanochemo-biological theories of cells and tissues are proposed.
胚胎发育、肿瘤发展等生理和病理过程,均涉及在多个时间和空间尺度上力学、化学与生物学诸多因素的复杂相互作用.本文介绍了生物组织与细胞力-化-生耦合理论的最新进展及其在癌症、免疫等疾病中的应用.首先,重点探讨了组织与细胞动力学过程力-化-生耦合建模所面临的关键问题.然后,介绍了力-化-生耦合的组织生长理论,该理论可以描述肿瘤等组织生长、重塑、老化等过程中的体积生长、结构演化等行为.之后,系统描述了细胞与组织在不同尺度上的稳定性现象和理论分析方法,尤其是力-化-生耦合机制所引起的动力学问题.进而,构建了力-化-生耦合的多尺度计算方法,用于研究细胞与组织的动力学过程,例如癌细胞的迁移和转移.此外,还讨论了在群体细胞动力学方面的若干实验与理论发现.最后,展望了细胞与组织的力-化-生耦合理论的发展趋势和临床应用前景.
基金
supported by the National Natural Science Foundation of China(Grant Nos.12032014,T2488101,and 12325209)。
