摘要
原发性肝癌是消化道常见恶性肿瘤之一,慢性肝炎的“炎癌转化”是慢性肝炎向肝癌演进的核心病理过程。慢性肝炎患者因长期存在非可控性炎症反应,导致肝组织反复损伤与修复,逐步发展为肝纤维化、肝硬化,最终通过基因突变及微环境失衡等机制完成恶性转化。慢性肝炎“炎癌转化”是连接慢性肝炎与肝癌的关键环节,其动态演变涉及湿、热、虚、毒、瘀等多种病机因素。其中,湿热与正虚为慢性肝炎“炎癌转化”的始动因素,而瘀毒互结则是推动恶性转化的核心病理产物。中医药基于“治未病”理念,通过多靶点调控炎症、代谢及细胞异常增殖等机制,有效延缓甚至阻断慢性肝炎“炎癌转化”进程,为肝癌防治提供重要策略与研究方向。
Primary liver cancer is one of the most common malignant tumors of the digestive system,and the“inflammation-to-cancer transformation”(ICT)of chronic hepatitis is the core pathological process of the progression of chronic hepatitis to liver cancer.Persistent and uncontrolled liver inflammation in patients with chronic hepatitis often leads to repeated liver tissue damage and repair,which gradually develops into liver fibrosis and cirrhosis,eventually leading to malignant transformation through the mechanisms such as gene mutation and microenvironment imbalance.ICT in chronic hepatitis is the key link between chronic hepatitis and liver cancer,and its dynamic evolution involves various pathogenic factors such as dampness,heat,deficiency,toxin,and stasis;among which damp-heat and vital energy deficiency are the initiating factors for ICT of chronic hepatitis,while intermingled stasis and toxin are the key pathological products that promote malignant transformation.Based on the concept of preventive treatment,traditional Chinese medicine can effectively delay and even block the ICT of chronic hepatitis by regulating inflammation,metabolism,and abnormal cell proliferation through multiple targets,which provides important strategies and research directions for the prevention and treatment of liver cancer.
作者
余思邈
王思慈
郑浩呈
孙永强
景婧
何婷婷
王丽苹
张傲哲
王鑫
丁霞
王睿林
YU Simiao;WANG Sici;ZHENG Haocheng;SUN Yongqiang;JING Jing;HE Tingting;WANG Liping;ZHANG Aozhe;WANG Xin;DING Xia;WANG Ruilin(Department of Traditional Chinese Medicine for Liver Disease,The Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《临床肝胆病杂志》
北大核心
2025年第9期1888-1895,共8页
Journal of Clinical Hepatology
基金
国家自然科学基金面上项目(81673806)
中国医药教育协会重大科学攻关问题和医药技术难题科研课题(2020KTY001)。
关键词
肝肿瘤
肝炎
慢性
中医药学
Liver Neoplasms
Hepatitis,Chronic
Traditional Chinese Medicine and Pharmacy
